Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 13/20 | 0.78 |
| ▸ | INSR | P06213 | 9/20 | 0.78 |
| ▸ | IGF1R | P08069 | 9/20 | 0.78 |
| ▸ | EGFR | P00533 | 10/20 | 0.73 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.72 |
| ▸ | AURKA | O14965 | 1/20 | 0.72 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.72 |
| ▸ | JAK2 | O60674 | 1/20 | 0.72 |
| ▸ | STK10 | O94804 | 1/20 | 0.72 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.72 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.72 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.72 |
| ▸ | ABL1 | P00519 | 1/20 | 0.72 |
| ▸ | CD74 | P04233 | 1/20 | 0.72 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.72 |
| ▸ | LCK | P06239 | 1/20 | 0.72 |
| ▸ | FYN | P06241 | 1/20 | 0.72 |
| ▸ | FES | P07332 | 1/20 | 0.72 |
| ▸ | CSF1R | P07333 | 1/20 | 0.72 |
| ▸ | YES1 | P07947 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16780916 | 1.00 | ALK (0.78) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL16780721 | 0.97 | ALK (0.74) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL15600820 | 0.97 | ALK (0.74) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL16780999 | 0.96 | ALK (0.72) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL15600815 | 0.95 | ALK (0.72) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL15600811 | 0.94 | ALK (0.71) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL15600769 | 0.94 | ALK (0.71) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL14150200 | 0.94 | ALK (0.74) | ALKINSRIGF1REGFREML4 | |
| SCHEMBL15600816 | 0.93 | ALK (0.73) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL22497639 | 0.93 | ALK (0.71) | ALKINSRIGF1REGFRCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119143806-B | Dimethyl phosphine oxide substituted aniline pyrimidine derivative targeting EGFR mutation, preparation method and application thereof, and medicine prepared from dimethyl phosphine oxide substituted aniline pyrimidine derivative | 四川大学华西医院 | 2025-03-11 | — | — | CN | disclosed |
| CN-119143806-A | Dimethyl phosphine oxide substituted aniline pyrimidine derivative targeting EGFR mutation, preparation method and application thereof, and medicine prepared from dimethyl phosphine oxide substituted aniline pyrimidine derivative | 四川大学华西医院 | 2024-12-17 | — | — | CN | disclosed |