SCHEMBL3120168

SCHEMBL3120168

COc1ccc(Oc2cnc3c(c2)CCC(=O)N3CC(=O)N2CCc3ccc(OC)cc3C2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 1/20 0.46
ALDH1A1 P00352 3/20 0.43
L3MBTL1 Q9Y468 2/20 0.43
ABCB1 P08183 1/20 0.43
ABCC1 P33527 1/20 0.43
ESR2 Q92731 2/20 0.42
ESR1 P03372 1/20 0.42
CHRM4 P08173 2/20 0.41
SPR P35270 1/20 0.41
MAPT P10636 3/20 0.40
POLB P06746 2/20 0.40
KDM4E B2RXH2 1/20 0.40
HPGD P15428 1/20 0.40
NR4A1 P22736 1/20 0.40
APEX1 P27695 1/20 0.40
RECQL P46063 1/20 0.40
CTDSP1 Q9GZU7 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
KMT2A Q03164 3/20 0.40
MEN1 O00255 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3122093 0.95 TAAR1 (0.46) TAAR1ALDH1A1L3MBTL1ABCB1ESR2
SCHEMBL3131972 0.95 MAPT (0.42) TAAR1ALDH1A1L3MBTL1ABCB1ABCC1
SCHEMBL3244950 0.91 TSHR (0.42) TAAR1ALDH1A1L3MBTL1ESR2ESR1
SCHEMBL3240895 0.90 TAAR1 (0.43) TAAR1ALDH1A1L3MBTL1ABCB1ABCC1
SCHEMBL13521643 0.89 KMT2A (0.46) TAAR1ALDH1A1L3MBTL1ESR2CHRM4
SCHEMBL3126513 0.88 ESR2 (0.45) TAAR1ALDH1A1L3MBTL1ABCB1ABCC1
SCHEMBL3117476 0.88 TAAR1 (0.41) TAAR1ALDH1A1L3MBTL1ABCB1ABCC1
SCHEMBL3119024 0.88 TAAR1 (0.46) TAAR1ALDH1A1L3MBTL1ABCB1ABCC1
SCHEMBL13521725 0.87 CYP11B1 (0.47) TAAR1ALDH1A1L3MBTL1ABCB1ESR2
SCHEMBL3246260 0.87 CYP11B1 (0.48) TAAR1ALDH1A1ABCB1ABCC1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010008777-A2 FUSED AZABICYCLIC PYRIDINES LIGAND PHARMACEUTICALS INC. (US) 2010-01-21 WO claimed
WO-2010008777-A2 FUSED AZABICYCLIC PYRIDINES LIGAND PHARMACEUTICALS INC. (US) 2010-01-21 WO disclosed