Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 1.00 |
| ▸ | PDE3B | Q13370 | 3/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 3/20 | 1.00 |
| ▸ | PDE1A | P54750 | 2/20 | 0.84 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.84 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.84 |
| ▸ | PDE2A | O00408 | 1/20 | 0.84 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.84 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.84 |
| ▸ | PDE6D | O43924 | 1/20 | 0.84 |
| ▸ | PDE8A | O60658 | 1/20 | 0.84 |
| ▸ | PDE9A | O76083 | 1/20 | 0.84 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.84 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.84 |
| ▸ | HTR1A | P08908 | 1/20 | 0.84 |
| ▸ | PDE6A | P16499 | 1/20 | 0.84 |
| ▸ | PDE6G | P18545 | 1/20 | 0.84 |
| ▸ | PDE4A | P27815 | 1/20 | 0.84 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.84 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lodenafil SCHEMBL1058 | 1.00 | PDE5A (1.00) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL1190 | 0.95 | PDE5A (0.90) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL31202702 | 0.95 | PDE5A (0.90) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL5010426 | 0.95 | PDE5A (0.90) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL30848678 | 0.94 | PDE5A (0.95) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL17342850 | 0.93 | PDE5A (1.00) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL29358004 | 0.93 | PDE5A (1.00) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL1423 | 0.93 | PDE5A (0.86) | PDE5APDE3BPDE3APDE1APDE1B | |
| Sildenafil SCHEMBL3399278 | 0.92 | PDE5A (0.95) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL17390175 | 0.92 | PDE5A (0.85) | PDE5APDE3BPDE3APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118878542-A | Haomaxidenafil derivative and synthesis method and application thereof | 西安市食品药品检验所 | 2024-11-01 | — | — | CN | disclosed |