Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 16/20 | 0.88 |
| ▸ | PIK3CD | O00329 | 15/20 | 0.88 |
| ▸ | PIK3CB | P42338 | 13/20 | 0.88 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.88 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.88 |
| ▸ | PLK4 | O00444 | 1/20 | 0.88 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.88 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.88 |
| ▸ | GAK | O14976 | 1/20 | 0.88 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.88 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.88 |
| ▸ | STK16 | O75716 | 1/20 | 0.88 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.88 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.88 |
| ▸ | NQO2 | P16083 | 1/20 | 0.88 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.88 |
| ▸ | JAK1 | P23458 | 1/20 | 0.88 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.88 |
| ▸ | TYK2 | P29597 | 1/20 | 0.88 |
| ▸ | AKT1 | P31749 | 1/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pictilisib SCHEMBL14859338 | 0.94 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C2A | |
| Pictilisib SCHEMBL29375636 | 0.94 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C2A | |
| Pictilisib SCHEMBL29387739 | 0.94 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C2A | |
| Pictilisib SCHEMBL190812 | 0.94 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C2A | |
| SCHEMBL190211 | 0.93 | PIK3CA (0.87) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C2A | |
| SCHEMBL190513 | 0.92 | PIK3CA (0.95) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C2A | |
| SCHEMBL10268492 | 0.92 | PIK3CA (0.84) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C2A | |
| Pictilisib SCHEMBL29915227 | 0.92 | ABCC4 (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C2A | |
| SCHEMBL958991 | 0.92 | PIK3CD (0.84) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C2A | |
| Pictilisib SCHEMBL29370279 | 0.92 | ABCC4 (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3230289-B1 | 7-(MORPHOLINYL)-2-(N-PIPERAZINYL) METHYL THIENO [2, 3-C]PYRIDINE DERIVATIVES AS ANTICANCER DRUGS | NATCO PHARMA LTD (IN) | 2019-08-14 | — | — | EP | disclosed |
| EP-2609192-A1 | IN VITRO HEPATIC DIFFERENTIATION | Cambridge Enterprise Limited (GB) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012025725-A1 | IN VITRO HEPATIC DIFFERENTIATION | CAMBRIDGE ENTERPRISE LIMITED (GB) | 2012-03-01 | — | — | WO | disclosed |