Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32677156 | 0.90 | PTPN1 (0.51) | PTPN1HDAC8ALDH1A1P2RX7POLB | |
| SCHEMBL2730308 | 0.90 | PTPN1 (0.51) | PTPN1HDAC8ALDH1A1P2RX7POLB | |
| SCHEMBL29798976 | 0.90 | PTPN1 (0.51) | PTPN1HDAC8ALDH1A1P2RX7POLB | |
| SCHEMBL32676714 | 0.90 | PTPN1 (0.51) | PTPN1HDAC8ALDH1A1P2RX7POLB | |
| SCHEMBL32676857 | 0.85 | PTPN1 (0.46) | PTPN1ALDH1A1P2RX7POLBMEN1 | |
| SCHEMBL32677157 | 0.85 | PTPN1 (0.46) | PTPN1ALDH1A1P2RX7POLBMEN1 | |
| SCHEMBL2730312 | 0.83 | PTPN1 (0.50) | PTPN1ALDH1A1P2RX7POLBMEN1 | |
| SCHEMBL31205610 | 0.83 | PTPN1 (0.42) | PTPN1HDAC8ALDH1A1CYP19A1NPSR1 | |
| SCHEMBL32677163 | 0.82 | PTPN1 (0.49) | PTPN1ALDH1A1P2RX7POLBMEN1 | |
| SCHEMBL16196417 | 0.81 | PTPN1 (0.49) | PTPN1ALDH1A1P2RX7POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024233766-A1 | MACROCYCLIC ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2024-11-14 | — | — | WO | disclosed |