SCHEMBL31222059

SCHEMBL31222059

CNC(=O)CCN(Cc1ccccc1)C(=O)c1sc2ccc(-c3cncc(OC)c3)cc2c1C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 1/20 0.39
HDAC1 Q13547 2/20 0.39
HDAC6 Q9UBN7 2/20 0.39
CDK7 P50613 1/20 0.39
PIK3CG P48736 6/20 0.38
PIK3CA P42336 4/20 0.38
FYN P06241 2/20 0.38
POLB P06746 1/20 0.37
GAA P10253 1/20 0.37
MAPT P10636 1/20 0.37
MCHR1 Q99705 1/20 0.36
AVPR1B P47901 1/20 0.36
DYRK1A Q13627 2/20 0.36
HSD17B2 P37059 1/20 0.35
CLK1 P49759 1/20 0.35
LPAR1 Q92633 1/20 0.35
ROCK2 O75116 1/20 0.35
MAPK10 P53779 1/20 0.35
ROCK1 Q13464 1/20 0.35
CDC42BPA Q5VT25 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31221979 0.90 MAPKAPK2 (0.36) PIK3CDHDAC1HDAC6PIK3CGPIK3CA
SCHEMBL31222067 0.89 PIK3CD (0.37) PIK3CDCDK7PIK3CGPIK3CAMAPT
SCHEMBL31222017 0.87 PIK3CG (0.37) PIK3CDCDK7PIK3CGPIK3CAPOLB
SCHEMBL31221974 0.86 CDK7 (0.43) PIK3CDCDK7PIK3CGPIK3CA
SCHEMBL31221945 0.86 PIK3CD (0.41) PIK3CDCDK7PIK3CGPIK3CAAVPR1B
SCHEMBL31221922 0.85 PIK3CG (0.36) PIK3CDCDK7PIK3CGPIK3CADYRK1A
SCHEMBL31221942 0.83 PIK3CG (0.37) PIK3CDPIK3CGPIK3CADYRK1A
SCHEMBL31221932 0.83 GSK3B (0.39) PIK3CDPIK3CGPIK3CAPOLBDYRK1A
SCHEMBL31221928 0.82 GSK3B (0.45) POLBGAAMAPTAVPR1BDYRK1A
SCHEMBL31221953 0.80 CREBBP (0.35) HDAC1HDAC6POLBMAPTLPAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024232599-A1 NOVEL BENZOTHIOPHENE DERIVATIVE INHIBITING BET PROTEIN AND COMPOSITION FOR TREATMENT OF CANCER, USING SAME 주식회사 베노바이오 2024-11-14 WO disclosed