Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 10/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR1E | P28566 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23296608 | 0.90 | TMEM97 (0.47) | TMEM97SIGMAR1HRH1HRH3HTR1A | |
| SCHEMBL23296610 | 0.90 | TMEM97 (0.47) | TMEM97SIGMAR1HRH1HRH3HTR1A | |
| SCHEMBL31133626 | 0.87 | TMEM97 (0.44) | TMEM97SIGMAR1HRH1HRH3HTR1A | |
| SCHEMBL31133683 | 0.85 | TMEM97 (0.42) | TMEM97SIGMAR1HRH1HRH3HTR1A | |
| SCHEMBL23338593 | 0.83 | NR1H2 (0.49) | TMEM97SIGMAR1HRH1HRH3HTR1A | |
| SCHEMBL27143761 | 0.83 | NR1H2 (0.49) | TMEM97SIGMAR1HRH1HRH3HTR1A | |
| SCHEMBL25889397 | 0.83 | TMEM97 (0.49) | TMEM97SIGMAR1HRH1HRH3HTR1A | |
| SCHEMBL31703372 | 0.82 | TMEM97 (0.48) | TMEM97SIGMAR1HRH1HRH3HTR1A | |
| SCHEMBL34468365 | 0.79 | FNTA (0.42) | TMEM97SIGMAR1HRH1HRH3HTR1A | |
| SCHEMBL34468453 | 0.79 | HDAC1 (0.43) | TMEM97SIGMAR1HRH1HRH3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688789-A1 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| WO-2024211663-A9 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2025-01-30 | — | — | WO | disclosed |
| WO-2024211663-A1 | CONDENSED MACROCYCLIC COMPOUNDS AS RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2024-10-10 | — | — | WO | disclosed |