Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 4/20 | 0.62 |
| ▸ | CDC7 | O00311 | 2/20 | 0.57 |
| ▸ | CDK1 | P06493 | 4/20 | 0.56 |
| ▸ | CDK9 | P50750 | 3/20 | 0.56 |
| ▸ | CDK7 | P50613 | 2/20 | 0.56 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.56 |
| ▸ | CCNH | P51946 | 1/20 | 0.56 |
| ▸ | POLA1 | P09884 | 1/20 | 0.54 |
| ▸ | SYK | P43405 | 6/20 | 0.51 |
| ▸ | WEE1 | P30291 | 1/20 | 0.49 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.48 |
| ▸ | PAK4 | O96013 | 2/20 | 0.48 |
| ▸ | PIM1 | P11309 | 2/20 | 0.48 |
| ▸ | PRKACA | P17612 | 2/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8855125 | 0.82 | CDK2 (0.72) | CDK2CDK1CDK9CDK7CCNT1 | |
| SCHEMBL27491045 | 0.77 | CDK2 (0.73) | CDK2CDK1CDK9CDK7CCNT1 | |
| SCHEMBL6446927 | 0.77 | CDK2 (1.00) | CDK2CDK1CDK9CDK7CCNT1 | |
| SCHEMBL653843 | 0.76 | SYK (0.80) | CDK2CDC7CDK1SYKPRKD3 | |
| SCHEMBL28251677 | 0.76 | CDK2 (0.70) | CDK2CDK1CDK9CDK7CCNT1 | |
| SCHEMBL27116918 | 0.75 | SMO (0.54) | CDK2CDC7CDK1CDK9SYK | |
| SCHEMBL4492404 | 0.75 | CDC7 (0.63) | CDK2CDC7CDK1CDK9CDK7 | |
| SCHEMBL29430392 | 0.75 | CDC7 (0.63) | CDK2CDC7CDK1CDK9CDK7 | |
| SCHEMBL30250674 | 0.74 | CDC7 (0.70) | CDK2CDC7CDK9CDK7SYK | |
| SCHEMBL29430407 | 0.74 | CDC7 (0.59) | CDK2CDC7CDK1CDK9CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024240118-A1 | PREPARATION FOR AND USE OF HETEROARYL DERIVATIVES | 广州智睿医药科技有限公司 | 2024-11-28 | — | — | WO | claimed |
| CN-119019454-A | Preparation and application of heteroaryl derivative | 广州智睿医药科技有限公司 | 2024-11-26 | — | — | CN | claimed |
| WO-2024240118-A1 | PREPARATION FOR AND USE OF HETEROARYL DERIVATIVES | 广州智睿医药科技有限公司 | 2024-11-28 | — | — | WO | disclosed |
| CN-119019454-A | Preparation and application of heteroaryl derivative | 广州智睿医药科技有限公司 | 2024-11-26 | — | — | CN | disclosed |