Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 11/20 | 0.32 |
| ▸ | RAF1 | P04049 | 2/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31235512 | 1.00 | KRAS (0.32) | KRASRAF1MAPK3MAPK1 | |
| SCHEMBL31234905 | 0.93 | KRAS (0.32) | KRASRAF1MAPK3MAPK1 | |
| SCHEMBL31235501 | 0.93 | KRAS (0.32) | KRASRAF1MAPK3MAPK1 | |
| SCHEMBL31235019 | 0.89 | KRAS (0.30) | KRASRAF1 | |
| SCHEMBL31234998 | 0.88 | KRAS (0.34) | KRASMAPK3MAPK1 | |
| SCHEMBL31234974 | 0.87 | — | — | |
| SCHEMBL31235105 | 0.86 | KRAS (0.32) | KRASRAF1MAPK3MAPK1 | |
| SCHEMBL31235533 | 0.86 | KRAS (0.32) | KRASRAF1MAPK3MAPK1 | |
| SCHEMBL31235305 | 0.86 | KRAS (0.31) | KRASRAF1 | |
| SCHEMBL31235345 | 0.86 | KRAS (0.31) | KRASRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024243025-A1 | NAPHTHYL-SUBSTITUTED PYRIDO[4,3-D]PYRIMIDINES AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | Ikena Oncology, Inc. (US) | 2024-11-28 | — | — | WO | disclosed |