Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 19/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.67 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.67 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3240493 | 0.94 | SCN9A (0.64) | SCN9AKCNH2SCN5A | |
| SCHEMBL3236267 | 0.90 | SCN9A (0.73) | SCN9AKCNH2SCN5A | |
| SCHEMBL3120681 | 0.90 | SCN9A (0.68) | SCN9AKCNH2SCN5A | |
| SCHEMBL3250021 | 0.89 | SCN9A (0.67) | SCN9AKCNH2SCN5A | |
| SCHEMBL3234165 | 0.89 | SCN9A (0.73) | SCN9AKCNH2SCN5A | |
| SCHEMBL3251032 | 0.87 | SCN9A (0.65) | SCN9AKCNH2SCN5A | |
| SCHEMBL3245242 | 0.87 | SCN9A (0.65) | SCN9AKCNH2SCN5A | |
| SCHEMBL3117833 | 0.87 | SCN9A (0.68) | SCN9AKCNH2SCN5A | |
| SCHEMBL3244979 | 0.87 | SCN9A (0.73) | SCN9AKCNH2SCN5A | |
| SCHEMBL3115533 | 0.87 | SCN9A (0.62) | SCN9AKCNH2SCN5AAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |