Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 16/20 | 0.76 |
| ▸ | JAK2 | O60674 | 3/20 | 0.70 |
| ▸ | JAK3 | P52333 | 2/20 | 0.70 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.51 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2565335 | 1.00 | NTRK1 (0.76) | NTRK1JAK2JAK3LIMK1LIMK2 | |
| SCHEMBL2573694 | 0.91 | NTRK1 (0.78) | NTRK1JAK2JAK3IGF1R | |
| SCHEMBL4696873 | 0.90 | NTRK1 (0.78) | NTRK1JAK2JAK3IGF1R | |
| SCHEMBL57691 | 0.90 | NTRK1 (0.78) | NTRK1JAK2JAK3IGF1R | |
| SCHEMBL3130155 | 0.89 | NTRK1 (0.88) | NTRK1JAK2JAK3IGF1R | |
| SCHEMBL17044023 | 0.89 | NTRK1 (0.88) | NTRK1JAK2JAK3IGF1R | |
| SCHEMBL2573790 | 0.87 | NTRK1 (0.61) | NTRK1JAK2JAK3IGF1R | |
| SCHEMBL2573786 | 0.87 | NTRK1 (0.61) | NTRK1JAK2JAK3IGF1R | |
| SCHEMBL2634350 | 0.86 | NTRK1 (1.00) | NTRK1JAK2JAK3IGF1R | |
| SCHEMBL3139815 | 0.86 | JAK2 (0.68) | NTRK1JAK2JAK3LIMK1LIMK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853602-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2010-07-14 | — | — | EP | disclosed |