Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ruxolitinib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 known ✓ | O60674 | 15/20 | 1.00 |
| ▸ | JAK1 known ✓ | P23458 | 14/20 | 1.00 |
| ▸ | JAK3 known ✓ | P52333 | 6/20 | 1.00 |
| ▸ | TYK2 known ✓ | P29597 | 3/20 | 1.00 |
| ▸ | ABL1 | P00519 | 3/20 | 1.00 |
| ▸ | DAPK3 | O43293 | 2/20 | 1.00 |
| ▸ | PAK4 | O96013 | 2/20 | 1.00 |
| ▸ | RET | P07949 | 2/20 | 1.00 |
| ▸ | LTK | P29376 | 2/20 | 1.00 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 1.00 |
| ▸ | CLK2 | P49760 | 2/20 | 1.00 |
| ▸ | TNK2 | Q07912 | 2/20 | 1.00 |
| ▸ | ROCK1 | Q13464 | 2/20 | 1.00 |
| ▸ | DYRK1A | Q13627 | 2/20 | 1.00 |
| ▸ | IKBKE | Q14164 | 2/20 | 1.00 |
| ▸ | NTRK3 | Q16288 | 2/20 | 1.00 |
| ▸ | NTRK2 | Q16620 | 2/20 | 1.00 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 1.00 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 1.00 |
| ▸ | CAMK1D | Q8IU85 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ruxolitinib SCHEMBL29349794 | 1.00 | JAK2 (1.00) | JAK2JAK1JAK3ABL1TYK2 | |
| Ruxolitinib SCHEMBL29677353 | 1.00 | JAK2 (1.00) | JAK2JAK1JAK3ABL1TYK2 | |
| Ruxolitinib SCHEMBL26927161 | 1.00 | JAK2 (1.00) | JAK2JAK1JAK3ABL1TYK2 | |
| Ruxolitinib SCHEMBL99225 | 1.00 | JAK2 (1.00) | JAK2JAK1JAK3ABL1TYK2 | |
| Ruxolitinib SCHEMBL101279 | 1.00 | JAK2 (1.00) | JAK2JAK1JAK3ABL1TYK2 | |
| Ruxolitinib SCHEMBL171319 | 1.00 | JAK2 (1.00) | JAK2JAK1JAK3ABL1TYK2 | |
| Ruxolitinib SCHEMBL26927158 | 1.00 | JAK2 (1.00) | JAK2JAK1JAK3ABL1TYK2 | |
| Ruxolitinib SCHEMBL29808249 | 1.00 | JAK2 (1.00) | JAK2JAK1JAK3ABL1TYK2 | |
| SCHEMBL99371 | 0.99 | JAK2 (0.98) | JAK2JAK1JAK3ABL1TYK2 | |
| SCHEMBL99245 | 0.99 | JAK2 (0.98) | JAK2JAK1JAK3ABL1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250205157-A1 | TOPICAL RUXOLITINIB FOAM | INCYTE CORPORATION (US) | 2025-06-26 | — | — | US | disclosed |
| US-20240398810-A1 | TOPICAL RUXOLITINIB FOAM | INCYTE CORPORATION (US) | 2024-12-05 | — | — | US | disclosed |
| WO-2024243225-A1 | TOPICAL RUXOLITINIB FOAM | INCYTE CORPORATION (US) | 2024-11-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240398810-A1 | TOPICAL RUXOLITINIB FOAM | JAK1, BRAF, CCR8 | JAK2 20/4885JAK1 1/4885JAK3 5/4885 |
| US-20250205157-A1 | TOPICAL RUXOLITINIB FOAM | JAK1, BRAF, CCR8 | JAK2 20/4885JAK1 1/4885JAK3 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.