Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.36 |
| ▸ | RET | P07949 | 3/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.34 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.33 |
| ▸ | PLK4 | O00444 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 2/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.32 |
| ▸ | PAK4 | O96013 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 2/20 | 0.32 |
| ▸ | LCK | P06239 | 2/20 | 0.32 |
| ▸ | CSF1R | P07333 | 2/20 | 0.32 |
| ▸ | MET | P08581 | 2/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.32 |
| ▸ | KIT | P10721 | 2/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.32 |
| ▸ | FLT1 | P17948 | 2/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.32 |
| ▸ | TYK2 | P29597 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31249530 | 1.00 | KDR (0.36) | KDRRETNTRK1NTRK2NTRK3 | |
| SCHEMBL4053575 | 0.88 | RET (0.37) | KDRRETFGFR1 | |
| SCHEMBL4053570 | 0.88 | RET (0.37) | KDRRETFGFR1 | |
| SCHEMBL4064842 | 0.88 | KDR (0.40) | KDRRETNTRK1NTRK2NTRK3 | |
| SCHEMBL4064833 | 0.88 | KDR (0.40) | KDRRETNTRK1NTRK2NTRK3 | |
| SCHEMBL28567548 | 0.84 | RET (0.35) | KDRRETFGFR1ABL1 | |
| SCHEMBL28567549 | 0.84 | RET (0.35) | KDRRETFGFR1ABL1 | |
| SCHEMBL30628346 | 0.84 | KDR (0.47) | KDRRETNTRK1NTRK2NTRK3 | |
| SCHEMBL28684897 | 0.83 | RET (0.37) | KDRRETFGFR1 | |
| SCHEMBL28684894 | 0.83 | RET (0.37) | KDRRETFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118994101-A | Arylindazole ring compound, preparation method, pharmaceutical composition and application | 安徽医科大学 | 2024-11-22 | — | — | CN | disclosed |