Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 2/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 12/20 | 0.34 |
| ▸ | AURKA | O14965 | 4/20 | 0.33 |
| ▸ | LCK | P06239 | 5/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | LYN | P07948 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | UBE2N | P61088 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | TEK | Q02763 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14467227 | 0.90 | AURKA (0.36) | MERTKTNK2AURKALCKABL1 | |
| SCHEMBL1787745 | 0.90 | AURKA (0.36) | MERTKTNK2AURKALCKABL1 | |
| SCHEMBL3125001 | 0.90 | AURKA (0.36) | MERTKTNK2AURKALCKABL1 | |
| SCHEMBL1785336 | 0.87 | MERTK (0.37) | MERTKTNK2AURKALCK | |
| SCHEMBL3125008 | 0.87 | MERTK (0.37) | MERTKTNK2AURKALCK | |
| SCHEMBL4788723 | 0.87 | MERTK (0.34) | MERTKTNK2AURKALCKABL1 | |
| SCHEMBL1786399 | 0.86 | ALOX5AP (0.41) | MERTKTNK2LCK | |
| SCHEMBL1785444 | 0.84 | MERTK (0.33) | MERTKTNK2AURKALCKAXL | |
| SCHEMBL1786037 | 0.84 | MERTK (0.33) | MERTKTNK2AURKALCKAXL | |
| SCHEMBL1786511 | 0.84 | MERTK (0.33) | MERTKTNK2AURKALCKAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966218-B1 | NOVEL, CYCLIC SUBSTITUTED FUROPYRIMIDINE DERIVATIVES AND USE THEREOF FOR TREATING CARDIOVASCULAR DISEASES | BAYER SCHERING PHARMA AG (DE) | 2010-07-14 | — | — | EP | disclosed |