Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1161652 | 1.00 | CYP3A4 (0.43) | CYP3A4CYP1A2CYP2C9CYP2C19TSHR | |
| SCHEMBL8466087 | 0.78 | TSHR (0.48) | CYP3A4CYP1A2CYP2C9CYP2C19TSHR | |
| SCHEMBL16269530 | 0.78 | TSHR (0.56) | CYP1A2CYP2C19TSHRKDM4ESMN1; SMN2 | |
| SCHEMBL25990458 | 0.76 | DYRK1A (0.41) | TSHRKDM4ESMN1; SMN2HPGDLMNA | |
| SCHEMBL16119585 | 0.76 | SRC (0.43) | TSHRKDM4ESMN1; SMN2HPGDMAPT | |
| SCHEMBL12844265 | 0.76 | LRRK2 (0.39) | TSHRKDM4ESMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL29642992 | 0.76 | KDM4E (0.56) | CYP3A4CYP1A2CYP2C9CYP2C19TSHR | |
| SCHEMBL17940666 | 0.76 | KDM4E (0.56) | CYP3A4CYP1A2CYP2C9CYP2C19TSHR | |
| SCHEMBL27607960 | 0.73 | KCNH2 (0.45) | CYP3A4CYP1A2CYP2C9CYP2C19TSHR | |
| SCHEMBL307615 | 0.73 | KDM4E (0.40) | CYP3A4CYP1A2CYP2C9CYP2C19TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118974035-A | 2-Aminoimidazole derivatives as PRMT5 inhibitors | 米拉蒂医疗股份有限公司 | 2024-11-15 | — | — | CN | disclosed |