SCHEMBL31263451

SCHEMBL31263451

CC(=O)N1C(C)(C)CC(c2ccc(N)c(C3=CCC(C)(C)CC3)n2)CC1(C)C

nearest known ligand 0.43

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CSF1R P07333 13/20 0.43
KIT P10721 1/20 0.43
FLT3 P36888 1/20 0.43
KDM5B Q9UGL1 1/20 0.33
TBK1 Q9UHD2 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31263131 0.83 CSF1R (0.39) CSF1RKITFLT3KDM5B
SCHEMBL31263168 0.82 CSF1R (0.38) CSF1RKITFLT3KDM5B
SCHEMBL31263008 0.80 CSF1R (0.48) CSF1RKITFLT3
SCHEMBL4238277 0.80 CSF1R (0.41) CSF1RKITFLT3KDM5BTBK1
SCHEMBL19264300 0.80 CSF1R (0.41) CSF1RKITFLT3KDM5BTBK1
SCHEMBL3653202 0.80 CSF1R (0.53) CSF1RKITFLT3KDM5BTBK1
SCHEMBL31263047 0.79 CSF1R (0.37) CSF1RKITFLT3KDM5B
SCHEMBL31263337 0.79 CSF1R (0.44) CSF1RKITFLT3KDM5BTBK1
Hydrochloric Acid SCHEMBL3657158 0.79 CSF1R (0.52) CSF1RKITFLT3KDM5BTBK1
Sulfuric Acid SCHEMBL18297749 0.79 CSF1R (0.53) CSF1RKITFLT3KDM5BTBK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709719-A1 5-CYANO-1H-IMIDAZOLE-2-CARBOXAMIDE COMPOUNDS AS CSF1R INHIBITORS Modulo Bio, Inc. (US) 2026-03-18 EP disclosed
WO-2024254440-A1 5-CYANO-1H-IMIDAZOLE-2-CARBOXAMIDE COMPOUNDS AS CSF1R INHIBITORS MODULO BIO, INC. (US) 2024-12-12 WO disclosed