Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 12/20 | 0.59 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.59 |
| ▸ | GSPT1 | P15170 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.53 |
| ▸ | IKZF2 | Q9UKS7 | 4/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 4/20 | 0.51 |
| ▸ | WIZ | O95785 | 3/20 | 0.46 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.43 |
| ▸ | SALL4 | Q9UJQ4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31264444 | 0.93 | CRBN (0.57) | CRBNDDB1GSPT1CYP2C19KCNH2 | |
| SCHEMBL31264424 | 0.90 | CRBN (0.66) | CRBNDDB1GSPT1CYP2C19KCNH2 | |
| SCHEMBL31264435 | 0.89 | CRBN (0.60) | CRBNDDB1GSPT1CYP2C19KCNH2 | |
| SCHEMBL31264408 | 0.87 | CRBN (0.69) | CRBNDDB1GSPT1CYP2C19KCNH2 | |
| SCHEMBL31264436 | 0.87 | CRBN (0.58) | CRBNDDB1GSPT1CYP2C19KCNH2 | |
| SCHEMBL1413745 | 0.87 | CRBN (0.66) | CRBNDDB1GSPT1CYP2C19KCNH2 | |
| SCHEMBL1413684 | 0.86 | CRBN (0.69) | CRBNDDB1GSPT1CYP2C19KCNH2 | |
| SCHEMBL31264443 | 0.86 | CRBN (0.56) | CRBNDDB1GSPT1CYP2C19KCNH2 | |
| SCHEMBL31264439 | 0.85 | CRBN (0.55) | CRBNDDB1GSPT1CYP2C19KCNH2 | |
| SCHEMBL31264420 | 0.84 | CRBN (0.62) | CRBNDDB1GSPT1CYP2C19KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024251301-A1 | GSPT1 PROTEIN DEGRADER CONTAINING OXIME STRUCTURE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 中国药科大学 | 2024-12-12 | — | — | WO | disclosed |
| CN-119080738-A | GSPT1 protein degradation agent containing oxime structure and preparation method and application thereof | 中国药科大学 | 2024-12-06 | — | — | CN | disclosed |