SCHEMBL31268847

SCHEMBL31268847

Cc1ccnc(Cn2c(-c3ccc(OC4CCCNCC4)cc3Cl)nc3c(OC4(C)CC4)ncnc32)c1

nearest known ligand 0.36

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ KCNH2 Q12809 1/20 0.36
▸ SCN5A Q14524 1/20 0.36
▸ SCN9A Q15858 1/20 0.36
▸ PIK3CD O00329 8/20 0.34
▸ DYRK1A Q13627 1/20 0.33
▸ ROCK1 Q13464 3/20 0.31
▸ KDM1A O60341 2/20 0.31
▸ USP7 Q93009 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31268925 0.97 KCNH2 (0.38) KCNH2SCN5ASCN9APIK3CDDYRK1A
SCHEMBL31269381 0.93 PIK3CD (0.38) KCNH2SCN5ASCN9APIK3CDDYRK1A
SCHEMBL30983782 0.90 KCNH2 (0.36) KCNH2SCN5ASCN9APIK3CD
SCHEMBL31269066 0.87 KCNH2 (0.37) KCNH2SCN5ASCN9APIK3CD
SCHEMBL31268763 0.87 KCNH2 (0.34) KCNH2SCN5ASCN9APIK3CD
SCHEMBL31268740 0.87 PDE2A (0.39) KCNH2SCN5ASCN9APIK3CD
SCHEMBL31268839 0.87 KCNH2 (0.36) KCNH2SCN5ASCN9APIK3CD
SCHEMBL30983481 0.86 KCNH2 (0.34) KCNH2SCN5ASCN9APIK3CD
SCHEMBL31269196 0.86 KCNH2 (0.35) KCNH2SCN5ASCN9APIK3CD
SCHEMBL31321958 0.86 PIK3CD (0.40) KCNH2SCN5ASCN9APIK3CDDYRK1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4689155-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS Astrazeneca AB (SE) 2026-02-11 — — EP disclosed
WO-2024201368-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS ASTRAZENECA AB (SE) 2024-10-03 — — WO disclosed
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