SCHEMBL31268933

SCHEMBL31268933

Cc1ccnc(Cn2c(-c3ccc(OC(C)CO)cc3Cl)nc3c(OC4(C)CC4)ncnc32)c1

nearest known ligand 0.34

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ PIK3CD O00329 3/20 0.34
▸ ABL1 P00519 2/20 0.31
▸ KCNH2 Q12809 1/20 0.31
▸ SCN5A Q14524 1/20 0.31
▸ SCN9A Q15858 1/20 0.31
▸ AGTR2 P50052 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30983382 0.89 PDE2A (0.34) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL30983510 0.89 PDE2A (0.34) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL30983461 0.89 PDE2A (0.34) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL30983456 0.88 PIK3CD (0.35) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL31269242 0.88 PIK3CD (0.32) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL31268935 0.88 PDE2A (0.34) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL31268819 0.87 PIK3CD (0.36) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL31269380 0.87 PDE2A (0.38) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL31268931 0.86 PDE8A (0.37) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL30983779 0.86 KCNH2 (0.36) PIK3CDKCNH2SCN5ASCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4689155-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS Astrazeneca AB (SE) 2026-02-11 — — EP disclosed
WO-2024201368-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS ASTRAZENECA AB (SE) 2024-10-03 — — WO disclosed
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