SCHEMBL31269441

SCHEMBL31269441

CNCc1ccc(-c2nc3c(OC4(C)CC4)ncnc3n2Cc2cc(C)ccn2)c(Cl)c1

nearest known ligand 0.36

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ KCNH2 Q12809 1/20 0.36
▸ SCN5A Q14524 1/20 0.36
▸ SCN9A Q15858 1/20 0.36
▸ PIK3CD O00329 3/20 0.32
▸ CNR1 P21554 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31269054 0.89 KCNH2 (0.34) KCNH2SCN5ASCN9APIK3CDCNR1
SCHEMBL31268930 0.89 KCNH2 (0.34) KCNH2SCN5ASCN9APIK3CDCNR1
SCHEMBL31269369 0.88 PIK3CD (0.35) KCNH2SCN5ASCN9APIK3CD
SCHEMBL31269411 0.88 KCNH2 (0.34) KCNH2SCN5ASCN9APIK3CDCNR1
SCHEMBL30984050 0.87 PIK3CD (0.36) KCNH2SCN5ASCN9APIK3CDCNR1
SCHEMBL31269187 0.87 PIK3CD (0.34) KCNH2SCN5ASCN9APIK3CD
SCHEMBL30983829 0.87 KCNH2 (0.34) KCNH2SCN5ASCN9APIK3CDCNR1
SCHEMBL30983779 0.87 KCNH2 (0.36) KCNH2SCN5ASCN9APIK3CDCNR1
SCHEMBL31269215 0.87 KCNH2 (0.34) KCNH2SCN5ASCN9APIK3CDCNR1
SCHEMBL30983484 0.87 PIK3CD (0.36) KCNH2SCN5ASCN9APIK3CDCNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4689155-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS Astrazeneca AB (SE) 2026-02-11 — — EP disclosed
WO-2024201368-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS ASTRAZENECA AB (SE) 2024-10-03 — — WO disclosed
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