Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 3/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.35 |
| ▸ | TNK2 | Q07912 | 4/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | ROS1 | P08922 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2447183 | 0.96 | SYK (0.40) | PRKCQSYKTRPV1BRD4CREBBP | |
| SCHEMBL2447413 | 0.93 | PRKCQ (0.45) | PRKCQSYKTRPV1BRD4CREBBP | |
| SCHEMBL3126963 | 0.93 | PRKCQ (0.36) | PRKCQSYKTRPV1BRD4CREBBP | |
| SCHEMBL2448252 | 0.85 | TNK2 (0.43) | SYKJAK2KCNH3TNK2CHEK1 | |
| SCHEMBL2448242 | 0.85 | TNK2 (0.43) | SYKJAK2KCNH3TNK2CHEK1 | |
| SCHEMBL2453169 | 0.84 | CREBBP (0.44) | PRKCQSYKTRPV1BRD4CREBBP | |
| SCHEMBL2449021 | 0.82 | TNK2 (0.49) | PRKCQJAK2KCNH3TNK2CHEK1 | |
| SCHEMBL2449020 | 0.82 | TNK2 (0.49) | PRKCQJAK2KCNH3TNK2CHEK1 | |
| SCHEMBL2848425 | 0.82 | TNK2 (0.49) | PRKCQJAK2KCNH3TNK2CHEK1 | |
| SCHEMBL2447187 | 0.81 | BRD4 (0.37) | SYKTRPV1BRD4CREBBPROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010053438-A1 | MODULATORS OF AMYLOID BETA. | ASTRAZENECA AB (SE) | 2010-05-14 | — | — | WO | disclosed |