Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cholecalciferol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR known ✓ | P11473 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 3/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 1.00 |
| ▸ | HSPD1 | P10809 | 2/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 2/20 | 1.00 |
| ▸ | HSPE1 | P61604 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | CDC25A | P30304 | 1/20 | 1.00 |
| ▸ | PGR | P06401 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 1/20 | 1.00 |
| ▸ | GLRA1 | P23415 | 1/20 | 1.00 |
| ▸ | DRD3 | P35462 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cholecalciferol SCHEMBL8082779 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPTALDH1A1CYP3A4 | |
| Cholecalciferol SCHEMBL13475366 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPTALDH1A1CYP3A4 | |
| Cholecalciferol SCHEMBL4545272 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPTALDH1A1CYP3A4 | |
| Cholecalciferol SCHEMBL2734123 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPTALDH1A1CYP3A4 | |
| Cholecalciferol SCHEMBL13717177 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPTALDH1A1CYP3A4 | |
| Cholecalciferol SCHEMBL4873580 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPTALDH1A1CYP3A4 | |
| Cholecalciferol SCHEMBL23878716 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPTALDH1A1CYP3A4 | |
| Cholecalciferol SCHEMBL13989117 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPTALDH1A1CYP3A4 | |
| Cholecalciferol SCHEMBL21264875 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPTALDH1A1CYP3A4 | |
| Cholecalciferol SCHEMBL20511118 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPTALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 31765 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12636251-B1 | Glycoside-containing aqueous formulations having a lipophilic active component | Doane Technology Group LLC (US) | 2026-05-26 | — | — | US | claimed |
| US-12636281-B2 | Dietary supplements to ameliorate dietary inadequacies related to brain health or neurodegenerative diseases, and methods to design dietary supplements | NEURORESERVE INC. (US) | 2026-05-26 | — | — | US | claimed |
| US-20260139860-A1 | PRODUCTS OF MANUFACTURE FOR THE TREATMENT, PREVENTION AND AMELIORATION OF MICROBIAL INFECTIONS | CENTRE FOR DIGESTIVE DISEASES (AU) | 2026-05-21 | — | — | US | claimed |
| US-20260137082-A1 | FUNGICIDAL COMPOSITIONS COMPRISING FLUDIOXONIL | SYNGENTA CROP PROTECTION AG (CH) | 2026-05-21 | — | — | US | claimed |
| EP-2991482-B1 | PACKAGED RODENTICIDAL BAIT | BASF AGRO BV (NL) | 2026-05-20 | — | — | EP | claimed |
| CN-122030461-A | Sheep milk with blood glucose and uric acid reducing activity and preparation method thereof | 陕西科技大学 | 2026-05-15 | — | — | CN | claimed |
| CN-122004461-A | Nutritional composite powder for promoting growth and bone age balance | 武汉景曦商业管理有限公司 | 2026-05-12 | — | — | CN | claimed |
| US-12622879-B2 | Transdermal delivery formulation | TRS II, LLC (US) | 2026-05-12 | — | — | US | claimed |
| US-20260124252-A1 | Dietary Pattern Directed Nutritional Supplementation Composition and Methods for Attenuating Age-Related Cognitive Decline or Enhancing Cognitive Function | NEURORESERVE INC (US) | 2026-05-07 | — | — | US | claimed |
| EP-3681481-B1 | COMPOSITIONS FOR PREVENTING AND TREATING HETEROTOPIC OSSIFICATION AND PATHOLOGIC CALCIFICATION | NOSTOPHARMA LLC (US) | 2026-05-06 | — | — | EP | claimed |
| EP-0182506-A2 | Membranes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-05-28 | — | — | EP | claimed |
| EP-0070588-B1 | METHOD OF PREPARING 1-ALPHA-HYDROXYVITAMIN D AND 1-ALPHA-HYDROXY-PREVITAMIN D COMPOUNDS, AND ADDUCT OF A PREVITAMIN D OR TACHYSTEROL COMPOUND WITH A SUITABLE DIENOPHILE | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1986-05-07 | — | — | EP | claimed |
| EP-0073465-B1 | CHOLECALCIFEROL DERIVATIVES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1986-02-05 | — | — | EP | claimed |
| EP-0148303-A1 | Dietetic composition | von Mletzko, Armin, Dr. (DE) | 1985-07-17 | — | — | EP | claimed |
| EP-0142973-A2 | Membranes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-05-29 | — | — | EP | claimed |
| US-4497800-A | Stable liquid diet composition | MEAD JOHNSON & COMPANY (US) | 1985-02-05 | — | — | US | claimed |
| US-4481356-A | MEDICAL DIAGNOSIS | THE UPJOHN COMPANY (US) | 1984-11-06 | — | — | US | claimed |
| EP-0122279-A1 | A PROCESS FOR PREPARING A CYCLOADDITION COMPOUND | WYNBERG, Hans (NL) | 1984-10-24 | — | — | EP | claimed |
| WO-1984001577-A1 | A PROCESS FOR PREPARING A CYCLOADDITION COMPOUND | WYNBERG HANS | 1984-04-26 | — | — | WO | claimed |
| US-4341774-A | Method for suppressing abnormal rise in immunological function and agent useful therefor | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1982-07-27 | — | — | US | claimed |