SCHEMBL3127054

SCHEMBL3127054

OC[C@@H](c1ccc(F)cc1)n1cnc2cc(Cl)c(Nc3cc(C4CC4)[nH]n3)nc21

nearest known ligand 0.68

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
NUAK1 O60285 1/20 0.68
NTRK1 P04629 16/20 0.60
IGF1R P08069 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3127072 1.00 NUAK1 (0.68) NUAK1NTRK1IGF1R
SCHEMBL3126574 0.92 NUAK1 (0.56) NUAK1NTRK1
SCHEMBL3126595 0.92 NUAK1 (0.56) NUAK1NTRK1
SCHEMBL3124301 0.87 NUAK1 (0.68) NUAK1NTRK1IGF1R
SCHEMBL3124294 0.87 NUAK1 (0.68) NUAK1NTRK1IGF1R
SCHEMBL3124443 0.86 NTRK1 (0.51) NUAK1NTRK1
SCHEMBL3124459 0.86 NTRK1 (0.51) NUAK1NTRK1
SCHEMBL3132279 0.86 NTRK1 (0.50) NUAK1NTRK1
SCHEMBL3132267 0.86 NTRK1 (0.50) NUAK1NTRK1
SCHEMBL3134973 0.85 NTRK1 (0.55) NUAK1NTRK1IGF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3458464-B1 STEREOSELECTIVE SYNTHESIS OF PHOSPHOROTHIOATE OLIGORIBONUCLEOTIDES ETH ZUERICH (CH) 2026-04-15 EP claimed
EP-3980554-B1 HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES HOFFMANN LA ROCHE (CH) 2025-03-26 EP claimed
EP-3884055-B1 DOUBLE AND INDUCIBLE SUICIDE GENE CONSTRUCT AND ITS USE IN GENE THERAPY CONSEJO SUPERIOR INVESTIGACION (ES) 2023-08-09 EP claimed
EP-3199165-B1 METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF KRAS BY ASYMMETRIC DOUBLE-STRANDED RNA DICERNA PHARMACEUTICALS INC (US) 2022-06-08 EP claimed
EP-2514758-B2 Methods and compositions for the specific inhibition of gene expression by double-stranded RNA HOPE CITY (US) 2021-06-23 EP claimed
EP-3087184-B1 METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GLYCOLATE OXIDASE (HAO1) BY DOUBLE-STRANDED RNA DICERNA PHARMACEUTICALS INC (US) 2019-07-03 EP claimed
EP-3218488-B1 ANTISENSE-OLIGONUCLEOTIDES AS INHIBITORS OF TGF-R SIGNALING Neurovision Pharma GmbH (DE) 2018-10-24 EP claimed
EP-1742958-B1 METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE-STRANDED RNA HOPE CITY (US) 2017-05-17 EP claimed
EP-2514758-B1 Methods and compositions for the specific inhibition of gene expression by double-stranded RNA HOPE CITY (US) 2017-04-19 EP claimed
EP-2756845-B1 Methods and compositions for the specific inhibition of KRAS by asymmetric double-stranded RNA DICERNA PHARMACEUTICALS INC (US) 2017-03-15 EP claimed
EP-0743573-B1 Method for obtaining image contrast migration imaging members XEROX CORP (US) 2000-09-06 EP claimed
EP-0673783-B1 Recording sheets containing purine, pyrimidine, benzimidazole, imidazolidine, urazole, pyrazole, triazole, benzotriazole, tetrazole, and pyrazine compounds XEROX CORP (US) 2000-07-05 EP claimed
EP-0719271-B1 5-(1-FLUORO-VINYL)-1H-PYRIMIDINE-2,4-DIONE DERIVATIVES USEFUL AS ANTINEOPLASTIC AGENTS MERRELL PHARMA INC (US) 1997-11-26 EP claimed
EP-0398231-B1 Nucleoside analogs ACAD OF SCIENCE CZECH REPUBLIC (CZ) 1997-07-16 EP claimed
EP-0630381-B1 ANTIVIRAL ACYCLIC PHOSPHONOMETHOXYALKYL SUBSTITUTED, ALKENYL AND ALKYNYL PURINE AND PYRIMIDINE DERIVATIVES ACAD OF SCIENCE CZECH REPUBLIC (CZ) 1997-04-09 EP claimed
EP-0540686-B1 2'-FLUOROFURANOSYL DERIVATIVES AND NOVEL METHOD OF PREPARING 2'-FLUOROPYRIMIDINE AND 2'-FLUOROPURINE NUCLEOSIDES US COMMERCE (US) 1995-08-30 EP claimed
EP-0494370-B1 Antiviral (phosphonomethoxy)methoxy purine/pyrimidine derivatives ACAD OF SCIENCE CZECH REPUBLIC (CS) 1995-06-28 EP claimed
EP-0272446-B1 NOVEL ANTIVIRAL AGENTS SRI INTERNATIONAL (US) 1992-11-11 EP claimed
EP-0506935-A1 NOVEL RIBONUCLEOSIDE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND DRUGS CONTAINING SAID COMPOUNDS PASTEUR MERIEUX SERUMS ET VACCINS, Société Anonyme : (FR) 1992-10-07 EP claimed
WO-1992006993-A1 NOVEL RIBONUCLEOSIDE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND DRUGS CONTAINING SAID COMPOUNDS PASTEUR MERIEUX SERUMS ET VACCINS (FR) 1992-04-30 WO claimed