Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WRN | Q14191 | 1/20 | 0.55 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.33 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31270538 | 0.91 | WRN (0.50) | WRNSRPK1ACHEMAPTALDH1A1 | |
| SCHEMBL31394433 | 0.89 | WRN (0.55) | WRNTBK1GPR119CFTRACHE | |
| Hydrochloric Acid SCHEMBL31270456 | 0.89 | WRN (0.53) | WRNSRPK1ACHEMAPTALDH1A1 | |
| SCHEMBL31270596 | 0.88 | WRN (0.58) | WRNSRPK1ACHEMAPTALDH1A1 | |
| SCHEMBL31394740 | 0.88 | WRN (0.57) | WRNGPR119ACHEMAPTALDH1A1 | |
| SCHEMBL31394560 | 0.87 | WRN (0.59) | WRNGPR119ACHEMAPTALDH1A1 | |
| SCHEMBL31393912 | 0.87 | WRN (0.55) | WRNGPR119ACHEMAPTALDH1A1 | |
| SCHEMBL31499645 | 0.87 | WRN (0.54) | WRNGPR119ACHEMAPTALDH1A1 | |
| SCHEMBL31057829 | 0.87 | WRN (0.55) | WRNGPR119ACHEMAPTALDH1A1 | |
| SCHEMBL31057843 | 0.87 | WRN (0.55) | WRNGPR119ACHEMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024220887-A1 | [1,2,4]TRIAZOLO[1,5-A]PYRIMIDINONE WRN INHIBITORS | NIMBUS WADJET, INC. (US) | 2024-10-24 | — | — | WO | disclosed |