Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | GPR183 | P32249 | 15/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.39 |
| ▸ | WNT3A | P56704 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3758316 | 1.00 | PIK3CA (0.48) | PIK3CAPIK3CGNPC1RAB9AGPR183 | |
| SCHEMBL14570174 | 1.00 | PIK3CA (0.48) | PIK3CAPIK3CGNPC1RAB9AGPR183 | |
| SCHEMBL3758312 | 1.00 | PIK3CA (0.48) | PIK3CAPIK3CGNPC1RAB9AGPR183 | |
| SCHEMBL4013347 | 0.82 | TSHR (0.45) | NPC1RAB9AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL4013346 | 0.82 | TSHR (0.45) | NPC1RAB9AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL18002576 | 0.76 | PIK3CA (0.51) | PIK3CAPIK3CGNPC1RAB9AGPR183 | |
| SCHEMBL497425 | 0.76 | PIK3CA (0.55) | PIK3CAPIK3CGNPC1RAB9AGPR183 | |
| SCHEMBL6142463 | 0.74 | PIK3CA (0.41) | PIK3CAPIK3CGNPC1RAB9AGPR183 | |
| SCHEMBL7267886 | 0.73 | PIK3CA (0.41) | PIK3CAPIK3CGNPC1RAB9AGPR183 | |
| SCHEMBL7267880 | 0.73 | PIK3CA (0.41) | PIK3CAPIK3CGNPC1RAB9AGPR183 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113135896-B | Methylpyrazole derivatives as RET inhibitors | 正大天晴药业集团股份有限公司 | 2024-12-06 | — | — | CN | disclosed |