Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 5/20 | 0.59 |
| ▸ | SRC | P12931 | 4/20 | 0.58 |
| ▸ | ABL1 | P00519 | 3/20 | 0.56 |
| ▸ | BRAF | P15056 | 6/20 | 0.55 |
| ▸ | EGFR | P00533 | 4/20 | 0.54 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 1/20 | 0.51 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31053459 | 0.83 | KIT (0.66) | KITSRCABL1BRAFEGFR | |
| SCHEMBL30904911 | 0.83 | KIT (0.71) | KITSRCABL1BRAFEGFR | |
| SCHEMBL20912769 | 0.83 | KIT (0.71) | KITSRCABL1BRAFEGFR | |
| SCHEMBL14704590 | 0.83 | KIT (0.66) | KITSRCABL1BRAFEGFR | |
| SCHEMBL20227773 | 0.82 | KIT (0.65) | KITSRCABL1BRAFEGFR | |
| SCHEMBL19986829 | 0.82 | KIT (0.68) | KITSRCABL1BRAFEGFR | |
| SCHEMBL4933270 | 0.82 | KIT (0.65) | KITSRCABL1BRAFEGFR | |
| SCHEMBL29614753 | 0.82 | KIT (0.65) | KITSRCABL1BRAFEGFR | |
| SCHEMBL22477848 | 0.81 | KIT (0.64) | KITSRCABL1BRAFEGFR | |
| SCHEMBL17208605 | 0.81 | KIT (0.64) | KITSRCABL1BRAFEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113135896-B | Methylpyrazole derivatives as RET inhibitors | 正大天晴药业集团股份有限公司 | 2024-12-06 | — | — | CN | disclosed |