Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR6 | P46095 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23761235 | 0.88 | EPHX2 (0.44) | GPR6PDE10AEPHX2POLBGAA | |
| SCHEMBL30505244 | 0.88 | EPHX2 (0.44) | GPR6PDE10AEPHX2POLBGAA | |
| Hydrochloric Acid SCHEMBL25401967 | 0.86 | EPHX2 (0.44) | GPR6PDE10AEPHX2POLBGAA | |
| SCHEMBL29844280 | 0.84 | KDM4E (0.47) | GPR6PDE10AEPHX2POLBGAA | |
| SCHEMBL6530291 | 0.84 | KDM4E (0.50) | GPR6EPHX2POLBGAAKDM4E | |
| SCHEMBL2297804 | 0.83 | POLB (0.41) | GPR6PDE10AEPHX2POLBGAA | |
| SCHEMBL3121941 | 0.81 | KDM4E (0.40) | GPR6PDE10AEPHX2POLBGAA | |
| SCHEMBL3117962 | 0.81 | KDM4E (0.40) | GPR6PDE10AEPHX2POLBGAA | |
| SCHEMBL16989684 | 0.80 | TRPC3 (0.44) | GPR6PDE10AEPHX2POLBGAA | |
| SCHEMBL16989683 | 0.80 | TRPC3 (0.44) | GPR6PDE10AEPHX2POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |