Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23317081 | 0.86 | USP30 (0.35) | USP2SMN1; SMN2AVPR1AUSP30DDB1 | |
| SCHEMBL21843465 | 0.78 | USP2 (0.49) | USP2SMN1; SMN2AVPR1ADDB1CRBN | |
| SCHEMBL21273181 | 0.76 | USP2 (0.40) | USP2SMN1; SMN2USP30KDM4EMAPT | |
| SCHEMBL21273179 | 0.76 | USP2 (0.40) | USP2SMN1; SMN2USP30KDM4EMAPT | |
| SCHEMBL21273182 | 0.76 | USP2 (0.40) | USP2SMN1; SMN2USP30KDM4EMAPT | |
| SCHEMBL1621681 | 0.76 | USP2 (0.43) | USP2SMN1; SMN2DDB1CRBNKDM4E | |
| SCHEMBL24417745 | 0.76 | USP2 (0.43) | USP2SMN1; SMN2DDB1CRBNKDM4E | |
| SCHEMBL22999578 | 0.75 | USP2 (0.38) | USP2SMN1; SMN2DDB1CRBNKDM4E | |
| SCHEMBL1528547 | 0.72 | USP2 (0.38) | USP2SMN1; SMN2DDB1CRBNKDM4E | |
| SCHEMBL1528546 | 0.72 | USP2 (0.38) | USP2SMN1; SMN2DDB1CRBNKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4705293-A1 | SPIRO-HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | Amgen Inc. (US) | 2026-03-11 | — | — | EP | disclosed |
| WO-2024229317-A1 | SPIRO-HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2024-11-07 | — | — | WO | disclosed |