Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 3/20 | 0.48 |
| ▸ | AKT2 | P31751 | 3/20 | 0.48 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.48 |
| ▸ | HTR2C | P28335 | 6/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12194067 | 0.87 | AKT2 (0.52) | AKT1AKT2AKT3HTTLRRK2 | |
| SCHEMBL925908 | 0.82 | AKT1 (0.57) | AKT1AKT2AKT3LRRK2MEN1 | |
| SCHEMBL16131658 | 0.81 | AKT1 (0.59) | AKT1AKT2AKT3ALDH1A1 | |
| SCHEMBL3944642 | 0.80 | AKT1 (0.44) | AKT1AKT2AKT3HTR2CDRD2 | |
| SCHEMBL22533475 | 0.80 | AKT1 (0.44) | AKT1AKT2AKT3HTR2CDRD2 | |
| Hydrochloric Acid SCHEMBL2262653 | 0.79 | AKT1 (0.44) | AKT1AKT2AKT3HTR2CDRD2 | |
| Hydrochloric Acid SCHEMBL2262657 | 0.79 | AKT1 (0.44) | AKT1AKT2AKT3HTR2CDRD2 | |
| SCHEMBL27919558 | 0.75 | AKT1 (0.56) | AKT1AKT2AKT3ALDH1A1LMNA | |
| SCHEMBL926441 | 0.75 | AKT1 (0.56) | AKT1AKT2AKT3ALDH1A1LMNA | |
| SCHEMBL12194065 | 0.73 | AKT2 (0.42) | AKT1AKT2AKT3HTTLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170863-A2 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009006567-A2 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-01-08 | — | — | WO | disclosed |