Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Guanethidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.52 |
| ▸ | CA1 | P00915 | 3/20 | 0.52 |
| ▸ | CA2 | P00918 | 3/20 | 0.52 |
| ▸ | CA9 | Q16790 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.43 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28128869 | 1.00 | CA12 (0.52) | CA12CA1CA2CA9ALDH1A1 | |
| Guanethidine SCHEMBL28254486 | 0.98 | CA12 (0.53) | CA12CA1CA2CA9ALDH1A1 | |
| Guanethidine SCHEMBL34753 | 0.98 | CA12 (0.53) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL8000929 | 0.98 | CA12 (0.53) | CA12CA1CA2CA9ALDH1A1 | |
| Guanethidine SCHEMBL15514378 | 0.96 | CA12 (0.52) | CA12CA1CA2CA9ALDH1A1 | |
| Guanethidine SCHEMBL22127050 | 0.96 | CA12 (0.52) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL10310276 | 0.96 | CA12 (0.50) | CA12CA1CA2CA9ALDH1A1 | |
| Guanethidine SCHEMBL22127049 | 0.94 | CA12 (0.50) | CA12CA1CA2CA9ALDH1A1 | |
| Guanethidine SCHEMBL9304898 | 0.91 | CA12 (0.46) | CA12CA1CA2CA9ALDH1A1 | |
| Guanethidine SCHEMBL28081160 | 0.91 | CA12 (0.47) | CA12CA1CA2CA9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119657107-A | Catalyst for catalyzing urea to prepare cyanamide and dicyandiamide simultaneously and application method thereof | 天津科技大学 | 2025-03-21 | — | — | CN | disclosed |
| EP-2203192-A1 | WOUND CARE FORMULATION | Northern Health And Social Care Trust (GB) | 2010-07-07 | — | — | EP | disclosed |
| WO-2009037500-A1 | WOUND CARE FORMULATION | NORTHERN HEALTH AND SOCIAL CARE TRUST (GB) | 2009-03-26 | — | — | WO | disclosed |