Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.74 |
| ▸ | CASP3 | P42574 | 1/20 | 0.74 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.74 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.74 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | USP7 | Q93009 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.49 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14305118 | 0.85 | POLB (1.00) | POLBCASP3SENP7SENP6NPC1 | |
| SCHEMBL407318 | 0.83 | USP7 (0.74) | POLBCASP3SENP7SENP6NPC1 | |
| Hydrochloric Acid SCHEMBL441062 | 0.81 | USP7 (0.72) | POLBCASP3SENP7SENP6NPC1 | |
| SCHEMBL463261 | 0.80 | POLB (0.68) | POLBCASP3SENP7SENP6NPC1 | |
| SCHEMBL13135840 | 0.80 | USP7 (0.74) | POLBCASP3SENP7SENP6NPC1 | |
| SCHEMBL408294 | 0.79 | POLB (0.67) | POLBCASP3SENP7SENP6NPC1 | |
| SCHEMBL440747 | 0.79 | POLB (0.67) | POLBCASP3SENP7SENP6NPC1 | |
| SCHEMBL13135838 | 0.78 | USP7 (0.76) | POLBCASP3SENP7SENP6NPC1 | |
| SCHEMBL5660093 | 0.77 | POLB (0.64) | POLBCASP3SENP7SENP6NPC1 | |
| SCHEMBL3241118 | 0.77 | POLB (0.63) | POLBCASP3SENP7SENP6NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |