⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4406594 | 1.00 | — | — | |
| SCHEMBL415931 | 1.00 | — | — | |
| Benzene SCHEMBL27678013 | 0.95 | SLC22A6 (0.43) | — | |
| Butadiene SCHEMBL15675640 | 0.95 | SLC22A6 (0.43) | — | |
| SCHEMBL4541049 | 0.80 | SLC22A6 (0.52) | — | |
| SCHEMBL6477452 | 0.80 | SLC22A6 (0.52) | — | |
| SCHEMBL15627215 | 0.80 | SLC22A6 (0.52) | — | |
| SCHEMBL15627216 | 0.80 | SLC22A6 (0.52) | — | |
| SCHEMBL15627217 | 0.80 | SLC22A6 (0.52) | — | |
| SCHEMBL9375070 | 0.80 | TSHR (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10676504-B2 | Method for preparing largazole analogs and uses thereof | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2020-06-09 | — | — | US | disclosed |
| CN-105940111-B | Preparation of olefins from 3-hydroxycarboxylic acids via 3-hydroxycarboxyl-nucleosidic acids | 环球生物能源公司 | 2020-03-27 | — | — | CN | disclosed |
| US-10017787-B2 | Production of alkenes from 3-hydroxycarboxylic acids via 3-hydroxycarboxyl-nucleotidylic acids | GLOBAL BIOENERGIES (FR) | 2018-07-10 | — | — | US | disclosed |
| US-20180044376-A1 | Method for Preparing Largazole Analogs and Uses Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-02-15 | — | — | US | disclosed |
| US-20160298139-A1 | PRODUCTION OF ALKENES FROM 3-HYDROXYCARBOXYLIC ACIDS VIA 3-HYDROXYCARBOXYL-NUCLEOTIDYLIC ACIDS | Scientist of Fortune, S.A. (LU) | 2016-10-13 | — | — | US | disclosed |
| EP-3077524-A1 | PRODUCTION OF ALKENES FROM 3-HYDROXYCARBOXYLIC ACIDS VIA 3-HYDROXYCARBOXYL-NUCLEOTIDYLIC ACIDS | Global Bioenergies (FR) | 2016-10-12 | — | — | EP | disclosed |
| US-9422580-B2 | Methods for biosynthesizing 1,3 butadiene | INVISTA NORTH AMERICA S.A.R.L. (US) | 2016-08-23 | — | — | US | disclosed |
| US-9422578-B2 | Methods for biosynthesizing 1,3 butadiene | INVISTA NORTH AMERICA S.A.R.L. (US) | 2016-08-23 | — | — | US | disclosed |
| US-9388163-B2 | Multifunctional radical quenchers for the treatment of mitochondrial dysfunction | ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2016-07-12 | — | — | US | disclosed |
| WO-2016081297-A1 | CYCLIC BORONIC ACID ESTER DERIVATIVES AND THERAPEUTIC USES THEREOF | REMPEX PHARMACEUTICALS, INC. (US) | 2016-05-26 | — | — | WO | disclosed |
| WO-2010009334-A1 | METHOD FOR PREPARING LARGAZOLE ANALOGS AND USES THEREOF | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2010-01-21 | — | — | WO | disclosed |
| US-7585846-B2 | Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof | UNIVERSITY OF ROCHESTER (US) | 2009-09-08 | — | — | US | disclosed |
| CN-100491326-C | 3-hydroxy olefine acid derivative and its preparation and application | CHINESE ACAD INST CHEMISTRY (CN) | 2009-05-27 | — | — | CN | disclosed |
| US-20080207903-A1 | Chemical Process | ASTRAZENECA UK LIMITED (GB) | 2008-08-28 | — | — | US | disclosed |
| US-20080207903-A1 | Chemical Process | ASTRAZENECA UK LIMITED (GB) | 2008-08-28 | — | — | US | disclosed |
| CN-101020639-A | 3-hydroxy olefine acid derivative and its prepn and application | CHINESE ACAD INST CHEMISTRY (CN) | 2007-08-22 | — | — | CN | disclosed |
| US-20070099845-A1 | Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof | ROCHESTER, UNIVERSITY OF | 2007-05-03 | — | — | US | disclosed |
| EP-1691818-A4 | COMPOUNDS FOR DELIVERING AMINO ACIDS OR PEPTIDES WITH ANTIOXIDANT ACTIVITY INTO MITOCHONDRIA AND USE THEREOF | UNIV ROCHESTER (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-1691818-A2 | COMPOUNDS FOR DELIVERING AMINO ACIDS OR PEPTIDES WITH ANTIOXIDANT ACTIVITY INTO MITOCHONDRIA AND USE THEREOF | University of Rochester (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005051978-A2 | COMPOUNDS FOR DELIVERING AMINO ACIDS OR PEPTIDES WITH ANTIOXIDANT ACTIVITY INTO MITOCHONDRIA AND USE THEREOF | UNIVERSITY OF ROCHESTER (US) | 2005-06-09 | — | — | WO | disclosed |