Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.41 |
| ▸ | BPTF | Q12830 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | UBE2T | Q9NPD8 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14503215 | 0.85 | CYP1A2 (0.75) | CYP1A2CNR2ALDH1A1MAPK1HTT | |
| SCHEMBL1770262 | 0.81 | CYP1A2 (0.69) | CYP1A2ALDH1A1HTTSMN1; SMN2BPTF | |
| SCHEMBL2866512 | 0.81 | CYP1A2 (0.40) | CYP1A2CNR2ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL29845748 | 0.76 | CYP1A2 (0.96) | CYP1A2CNR2ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL30561625 | 0.76 | CYP1A2 (0.57) | CYP1A2CNR2ALDH1A1MAPK1HTT | |
| SCHEMBL25106007 | 0.76 | CYP1A2 (0.57) | CYP1A2CNR2ALDH1A1MAPK1HTT | |
| SCHEMBL421732 | 0.76 | CYP1A2 (0.96) | CYP1A2CNR2ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL16134879 | 0.76 | CYP1A2 (0.57) | CYP1A2ALDH1A1 | |
| SCHEMBL4020520 | 0.76 | CYP1A2 (0.57) | CYP1A2CNR2ALDH1A1MAPK1HTT | |
| SCHEMBL13750688 | 0.76 | CYP1A2 (0.57) | CYP1A2CNR2ALDH1A1MAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |