Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30980411 | 0.81 | CYP1A2 (0.61) | HRH4ROCK1CLK1DYRK1AMAPT | |
| SCHEMBL31295578 | 0.80 | MAPT (0.68) | ROCK1CA1CA9MAPTCYP1A2 | |
| SCHEMBL12466875 | 0.79 | HRH4 (0.57) | HRH4ROCK1CLK1DYRK1AMAPT | |
| SCHEMBL8524119 | 0.79 | HRH4 (0.50) | HRH4ROCK1CLK1DYRK1AMAPT | |
| SCHEMBL30828868 | 0.79 | HRH4 (0.57) | HRH4ROCK1CLK1DYRK1AMAPT | |
| SCHEMBL31295384 | 0.76 | SMN1; SMN2 (0.47) | CA1CA9MAPTCYP1A2CYP3A4 | |
| SCHEMBL31295492 | 0.76 | NPC1 (0.56) | ROCK1MAPTCYP1A2CYP3A4NPC1 | |
| SCHEMBL31295442 | 0.76 | USP30 (0.47) | CA1CA9MAPTCYP1A2CYP3A4 | |
| SCHEMBL1812266 | 0.75 | HRH4 (0.58) | HRH4ROCK1CLK1DYRK1AMAPT | |
| SCHEMBL31295435 | 0.74 | PIK3CG (0.46) | CA1CA9CLK1DYRK1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4701635-A1 | 1,2,4-TRIAZOLE-3-THIONE INHIBITORS OF TREX2 FOR USE IN THE TREATMENT OF PSORIASIS, ATOPIC DERMATITIS OR ICHTHYOSIS | Universitat De Barcelona (ES) | 2026-03-04 | — | — | EP | disclosed |
| WO-2024223907-A1 | 1,2,4-TRIAZOLE-3-THIONE INHIBITORS OF TREX2 FOR USE IN THE TREATMENT OF PSORIASIS, ATOPIC DERMATITIS OR ICHTHYOSIS | UNIVERSITAT DE BARCELONA (ES) | 2024-10-31 | — | — | WO | disclosed |