Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mesalamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 2/20 | 1.00 |
| ▸ | ALOX5 known ✓ | P09917 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 1.00 |
| ▸ | HPGD | P15428 | 3/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | THRB | P10828 | 2/20 | 1.00 |
| ▸ | RECQL | P46063 | 2/20 | 1.00 |
| ▸ | KDR | P35968 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | TNF | P01375 | 1/20 | 1.00 |
| ▸ | HSPD1 | P10809 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | CASP1 | P29466 | 1/20 | 1.00 |
| ▸ | BRCA1 | P38398 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mesalamine SCHEMBL29354798 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1MEN1KMT2ATDP1 | |
| Mesalamine SCHEMBL28077836 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1MEN1KMT2ATDP1 | |
| Mesalamine SCHEMBL1967328 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1MEN1KMT2ATDP1 | |
| Mesalamine SCHEMBL2680203 | 0.98 | KDM4E (0.96) | KDM4EALDH1A1MEN1KMT2ATDP1 | |
| Mesalamine SCHEMBL6517036 | 0.98 | MEN1 (0.96) | KDM4EALDH1A1MEN1KMT2ATDP1 | |
| Mesalamine SCHEMBL15329203 | 0.98 | KDM4E (0.96) | KDM4EALDH1A1MEN1KMT2ATDP1 | |
| Mesalamine SCHEMBL2679950 | 0.98 | KDM4E (0.96) | KDM4EALDH1A1MEN1KMT2ATDP1 | |
| Mesalamine SCHEMBL2680533 | 0.98 | KDM4E (0.96) | KDM4EALDH1A1MEN1KMT2ATDP1 | |
| Mesalamine SCHEMBL9688231 | 0.98 | KDM4E (0.96) | KDM4EALDH1A1MEN1KMT2ATDP1 | |
| Mesalamine SCHEMBL10493008 | 0.98 | KDM4E (0.96) | KDM4EALDH1A1MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 57034 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12636255-B2 | Nongranulated compressed tablets of mesalamine, and process of preparation thereof | ATOZ PHARMACEUTICALS PVT LTD (IN) | 2026-05-26 | — | — | US | claimed |
| CN-121202992-B | Novel long-acting Amylin receptor agonist and application thereof | Hangzhou Nuo Ao Biopharmaceutical Technology Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122075452-A | Application of phyllanthin in preparation of medicines for treating or preventing colonitis | — | 2026-05-26 | — | — | CN | claimed |
| US-20260138973-A1 | SUBSTITUTED PYRIDINES FOR USE IN TREATING OR PREVENTING INFLAMMATORY DISEASES OR DISEASES ASSOCIATED WITH AN UNDESIRABLE IMMUNE RESPONSE | SITRYX THERAPEUTICS LTD (GB) | 2026-05-21 | — | — | US | claimed |
| WO-2026103879-A1 | USE OF BIPHENYL-CONTAINING COMPOUND FOR TREATING INFLAMMATORY BOWEL DISEASE | 正大天晴药业集团股份有限公司 | 2026-05-21 | — | — | WO | claimed |
| US-20260137680-A1 | NOVEL COMPOUNDS | SITRYX THERAPEUTICS LTD (GB) | 2026-05-21 | — | — | US | claimed |
| CN-122070479-A | Ultrasonic indicating device and method for monitoring ultrasonic treatment | JP实验室股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-119280137-B | Soluble microneedle based on metal-amino acid/peptide/drug coordination nano-particles and preparation method and application thereof | 中国药科大学 | 2026-05-19 | — | — | CN | claimed |
| WO-2026098592-A1 | USE OF HETEROCYCLIC COMPOUND AND COMPLEX FORMED BY HETEROCYCLIC COMPOUND AND PHARMACEUTICALLY ACCEPTABLE ACID | 湖北生物医药产业技术研究院有限公司 | 2026-05-15 | — | — | WO | claimed |
| EP-4057998-B1 | PROCESS FOR MANUFACTURING A PHARMACEUTICAL COMPOSITION FOR ORAL INTAKE AND DRUG RELEASE IN THE COLON | ETHYPHARM SA (FR) | 2026-05-13 | — | — | EP | claimed |
| US-4344909-A | Thermochromic composition | N.V. RAYCHEM S.A. (BE) | 1982-08-17 | — | — | US | claimed |
| US-4336331-A | Method for assaying the activity of γ-glutamyl transpeptidase in serum | NITTO BOSEKI CO., LTD. (JP) | 1982-06-22 | — | — | US | claimed |
| US-RE30809-E | Method of preparation of 3-(3-carboxy-4-hydroxyphenyl)-4,5-dihydro-2-phenylbenz [e]indole and valuable intermediates related thereto | AMERICAN HOECHST CORPORATION (US) | 1981-12-01 | — | — | US | claimed |
| US-4298595-A | TREATMENT OF ULCERATIVE COLITIS; CLEAVAGE BY INTESTINAL BACTERIA | DYNAPOL (US) | 1981-11-03 | — | — | US | claimed |
| WO-1981002671-A1 | PHARMACEUTICAL COMPOSITION AND METHOD FOR THE TREATMENT OF COLITIS ULCEROSA AND CROHN'S DISEASE BY ORAL ADMINISTRATION | FERRING FARMA LAB (DK) | 1981-10-01 | — | — | WO | claimed |
| US-4234680-A | ALKALI METAL METABISULFITE STOPS COLOR DEVELOPMENT | CALBIOCHEM-BEHRING CORP. (US) | 1980-11-18 | — | — | US | claimed |
| US-4211777-A | GASTROINTESTINAL DISORDERS | FISONS LIMITED (GB) | 1980-07-08 | — | — | US | claimed |
| US-4137080-A | POLYFUNCTIONAL COUPLER AND DEVELOPER | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1979-01-30 | — | — | US | claimed |
| US-4066659-A | METHOD OF PREPARATION OF 3-(3-CARBOXY-4-HYDROXYPHENYL)-4,5-DIHYDRO-2-PHENYLBENZ (E) INDOLE AND VALUABLE INTERMEDIATES RELATED THERETO | AMERICAN HOECHST CORPORATION (US) | 1978-01-03 | — | — | US | claimed |
| US-4017477-A | 3-Halogeno-6-hydroxy-pyridone-(2) azo dyestuffs | CIBA-GEIGY AG (CH) | 1977-04-12 | — | — | US | claimed |