Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 6/20 | 0.46 |
| ▸ | CCND1 | P24385 | 6/20 | 0.46 |
| ▸ | CCND2 | P30279 | 5/20 | 0.46 |
| ▸ | CCND3 | P30281 | 5/20 | 0.46 |
| ▸ | AURKA | O14965 | 12/20 | 0.45 |
| ▸ | CDK1 | P06493 | 12/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 11/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL343799 | 0.82 | CDK4 (0.62) | CDK4CCND1CCND2CCND3AURKA | |
| SCHEMBL31299864 | 0.82 | CDK4 (0.45) | CDK4CCND1CCND2CCND3AURKA | |
| SCHEMBL31299830 | 0.81 | CDK1 (0.50) | CDK4CCND1CCND2CCND3AURKA | |
| SCHEMBL344028 | 0.80 | AURKA (0.52) | CDK4CCND1CCND2CCND3AURKA | |
| SCHEMBL1355464 | 0.80 | CDK4 (0.57) | CDK4CCND1CCND2CCND3AURKA | |
| SCHEMBL31299868 | 0.78 | CDK1 (0.42) | CDK4CCND1CCND2CCND3AURKA | |
| SCHEMBL343460 | 0.77 | CDK4 (0.62) | CDK4CCND1CCND2CCND3AURKA | |
| SCHEMBL12174918 | 0.76 | JAK1 (0.47) | CDK4CCND1CCND2CCND3AURKA | |
| SCHEMBL31299846 | 0.76 | CDK2 (0.49) | CDK4CCND1CCND2CCND3AURKA | |
| SCHEMBL343484 | 0.75 | AURKA (0.46) | CDK4CCND1CCND2CCND3AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024238570-A1 | CDK2 INHIBITOR PYRAZOLOPYRIMIDINE COMPOUNDS | ALEKSIA THERAPEUTICS, INC. (US) | 2024-11-21 | — | — | WO | disclosed |