Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GALR3 | O60755 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29799042 | 1.00 | ESR2 (0.66) | ESR2TSHRPTPN5ALDH1A1MEN1 | |
| SCHEMBL27963955 | 1.00 | ESR2 (0.66) | ESR2TSHRPTPN5ALDH1A1MEN1 | |
| Bromide SCHEMBL28805556 | 0.98 | ESR2 (0.63) | ESR2TSHRPTPN5ALDH1A1MEN1 | |
| SCHEMBL22841683 | 0.88 | ESR2 (0.53) | ESR2TSHRPTPN5ALDH1A1MEN1 | |
| SCHEMBL31410710 | 0.87 | ESR2 (0.76) | ESR2TSHRPTPN5ALDH1A1TRPA1 | |
| SCHEMBL10533916 | 0.87 | ESR2 (0.51) | ESR2TSHRPTPN5ALDH1A1MEN1 | |
| SCHEMBL20405268 | 0.86 | ESR2 (0.63) | ESR2TSHRPTPN5ALDH1A1TRPA1 | |
| SCHEMBL2016996 | 0.83 | ESR2 (0.70) | ESR2TSHRPTPN5ALDH1A1TRPA1 | |
| SCHEMBL23624588 | 0.82 | ESR2 (0.46) | ESR2TSHRALDH1A1MAPTHPGD | |
| SCHEMBL18406711 | 0.82 | ESR2 (0.46) | ESR2TSHRALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 848 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114436833-B | Preparation method of telmisartan key intermediate 4' -bromomethyl biphenyl-2-carboxylate | 南京红太阳医药研究院有限公司 | 2024-12-24 | — | — | CN | claimed |
| CN-118956301-A | Electrolytic adhesive containing stable polymer and preparation method thereof | 浙江中特化工有限公司 | 2024-11-15 | — | — | CN | claimed |
| CN-118510512-A | Novel process for the preparation of 4'- (bromomethyl) [1,1' -biphenyl ] -2-carbonitrile | 阿尔第实业有限公司 | 2024-08-16 | — | — | CN | claimed |
| CN-114733526-B | Nickel-supported porous carbon material catalyst and preparation method and application thereof | 浙江天宇药业股份有限公司 | 2024-05-17 | — | — | CN | claimed |
| CN-114733575-B | Palladium-supported molecular sieve catalyst and preparation method and application thereof | 浙江天宇药业股份有限公司 | 2024-04-09 | — | — | CN | claimed |
| WO-2023157026-A1 | A NOVEL PROCESS FOR THE PREPARATION OF 4'-(BROMOMETHYL)[1,1'-BIPHENYL]-2-CARBONITRILE | AARTI INDUSTRIES LIMITED (IN) | 2023-08-24 | — | — | WO | claimed |
| CN-114605393-B | Method for preparing losartan by micro-channel continuous flow | 浙江工业大学 | 2023-06-27 | — | — | CN | claimed |
| CN-112661666-B | Process for catalytic synthesis of 2-cyano-4' -methyl biphenyl | 南京工业大学 | 2023-04-21 | — | — | CN | claimed |
| CN-115594589-A | 4. A , Preparation method of (E) -methyl biphenyl-2-carboxylic acid methyl ester | 济南大学（CN） | 2023-01-13 | — | — | CN | claimed |
| CN-110105242-B | Continuous synthesis method of 2-cyano-4' -methyl biphenyl | 山东普洛汉兴医药有限公司 | 2022-11-11 | — | — | CN | claimed |
| US-5922898-A | Process for preparing biaryl compounds | CATALYTICA PHARMACEUTICALS, INC. (US) | 1999-07-13 | — | — | US | claimed |
| US-5892094-A | Process for preparing 4'-methyl-2-cyanobiphenyl | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 1999-04-06 | — | — | US | claimed |
| EP-0709369-B1 | Method for producing 4'-bromomethyl-2-cyanobiphenyl | SUMIKA FINE CHEMICALS CO LTD (JP) | 1999-01-13 | — | — | EP | claimed |
| EP-0853081-A1 | Process for preparing 4'-methyl-2-cyanobiphenyl | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 1998-07-15 | — | — | EP | claimed |
| WO-1998016486-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1998-04-23 | — | — | WO | claimed |
| WO-1998009941-A1 | METHOD FOR PREPARING A CYANOBIPHENYL | SANOFI (FR) | 1998-03-12 | — | — | WO | claimed |
| US-5621134-A | Method for producing 4'-bromomethyl-2-cyanobiphenyl | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 1997-04-15 | — | — | US | claimed |
| EP-0566468-B1 | Process for the preparation of a biphenyl derivative | SANOFI SA (FR) | 1997-01-22 | — | — | EP | claimed |
| EP-0709369-A1 | Method for producing 4'-bromomethyl-2-cyanobiphenyl | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 1996-05-01 | — | — | EP | claimed |
| US-5288895-A | Reacting a benzonitrile halide with methylphenylmagnisium halide in the presence of manganous salt, hydrolyzing the forming complexes | ELF SANOFI (FR) | 1994-02-22 | — | — | US | claimed |