Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK3 | Q13188 | 8/20 | 0.55 |
| ▸ | STK4 | Q13043 | 7/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.55 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.48 |
| ▸ | MERTK | Q12866 | 9/20 | 0.48 |
| ▸ | AXL | P30530 | 8/20 | 0.48 |
| ▸ | MET | P08581 | 4/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31301696 | 0.90 | STK3 (0.59) | STK3STK4LRRK2BRAFTNNI3K | |
| SCHEMBL31301605 | 0.89 | LRRK2 (0.55) | STK3STK4LRRK2BRAFTNNI3K | |
| SCHEMBL31301567 | 0.85 | STK3 (0.58) | STK3STK4LRRK2MERTKAXL | |
| SCHEMBL31301607 | 0.79 | LRRK2 (0.59) | STK3STK4LRRK2MERTKAXL | |
| SCHEMBL31301757 | 0.75 | LRRK2 (0.58) | STK3STK4LRRK2MERTKAXL | |
| SCHEMBL31301715 | 0.75 | LRRK2 (0.55) | STK3STK4LRRK2MERTKAXL | |
| SCHEMBL31301590 | 0.74 | LRRK2 (0.57) | STK3STK4LRRK2MERTKAXL | |
| SCHEMBL31301784 | 0.72 | LRRK2 (0.61) | STK3STK4LRRK2MERTKAXL | |
| SCHEMBL3450928 | 0.72 | JAK2 (0.46) | AURKAJAK2CDK2JAK3 | |
| SCHEMBL31301556 | 0.72 | LRRK2 (1.00) | STK3STK4LRRK2METCDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250051337-A1 | INHIBITORS OF SERINE/THREONINE PROTEIN KINASE STK3 OR STK4 AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute | 2025-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250051337-A1 | INHIBITORS OF SERINE/THREONINE PROTEIN KINASE STK3 OR STK4 AND USES THEREOF | STK3, STK4, STK36 | STK3 1/4885STK4 2/4885LRRK2 210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.