Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 19/20 | 0.84 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.84 |
| ▸ | SCN4A | P35499 | 1/20 | 0.84 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.84 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.68 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15947682 | 0.92 | SCN9A (1.00) | SCN9ASCN5ASCN4ASCN3AKCNH2 | |
| SCHEMBL3249743 | 0.91 | SCN9A (0.84) | SCN9ASCN5ASCN4ASCN3AKCNH2 | |
| SCHEMBL3240982 | 0.89 | SCN9A (0.82) | SCN9ASCN5ASCN4ASCN3AKCNH2 | |
| SCHEMBL3247949 | 0.86 | SCN9A (0.70) | SCN9ASCN5ASCN4ASCN3AKCNH2 | |
| SCHEMBL3250442 | 0.86 | SCN9A (0.63) | SCN9ASCN5ASCN4ASCN3AKCNH2 | |
| SCHEMBL3247266 | 0.84 | SCN9A (0.86) | SCN9ASCN5ASCN4ASCN3AKCNH2 | |
| SCHEMBL3247552 | 0.84 | SCN9A (0.85) | SCN9ASCN5ASCN4ASCN3AKCNH2 | |
| SCHEMBL3243044 | 0.83 | SCN9A (0.85) | SCN9ASCN5ASCN4ASCN3AKCNH2 | |
| SCHEMBL3128064 | 0.83 | SCN9A (0.85) | SCN9ASCN5ASCN4ASCN3AKCNH2 | |
| SCHEMBL17722150 | 0.82 | SCN9A (1.00) | SCN9ASCN5ASCN4ASCN3AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |