Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 10/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 10/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 10/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | TP53 | P04637 | 4/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 3/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 3/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 3/20 | 1.00 |
| ▸ | NPC1 | O15118 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | MTOR | P42345 | 2/20 | 1.00 |
| ▸ | RAB9A | P51151 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 2/20 | 1.00 |
| ▸ | THPO | P40225 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 5/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.97 |
| ▸ | MAPT | P10636 | 3/20 | 0.97 |
| ▸ | GMNN | O75496 | 2/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indatraline SCHEMBL585770 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP3A4TP53 | |
| Indatraline SCHEMBL29516308 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP3A4TP53 | |
| Indatraline SCHEMBL11128740 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP3A4TP53 | |
| Indatraline SCHEMBL9252635 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP3A4TP53 | |
| (R,S)-Indatraline SCHEMBL9252640 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP3A4TP53 | |
| (R,S)-Indatraline SCHEMBL29516529 | 0.98 | MEN1 (1.00) | SLC6A2SLC6A4SLC6A3CYP3A4TP53 | |
| Indatraline SCHEMBL467134 | 0.98 | MEN1 (1.00) | SLC6A2SLC6A4SLC6A3CYP3A4TP53 | |
| Indatraline SCHEMBL5436564 | 0.98 | MEN1 (1.00) | SLC6A2SLC6A4SLC6A3CYP3A4TP53 | |
| Sertraline SCHEMBL3947169 | 0.87 | MEN1 (1.00) | SLC6A2SLC6A4SLC6A3CYP3A4TP53 | |
| Sertraline SCHEMBL137619 | 0.87 | MEN1 (1.00) | SLC6A2SLC6A4SLC6A3CYP3A4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025003193-A1 | SERTRALINE AND INDATRALINE FOR DISRUPTING INTRACELLULAR CHOLESTEROL TRAFFICKING AND SUBSEQUENTLY INDUCING LYSOSOMAL DAMAGE AND ANTI-TUMOR IMMUNITY | Institut National de la Santé et de la Recherche Médicale (FR) | 2025-01-02 | — | — | WO | disclosed |