Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.55 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | PDE1A | P54750 | 1/20 | 0.44 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.44 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3132126 | 0.91 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3131361 | 0.86 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3132049 | 0.83 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL3131347 | 0.80 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL2905266 | 0.77 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL1157541 | 0.75 | PDE4D (0.69) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL2902041 | 0.75 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL2907952 | 0.75 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3121240 | 0.75 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3118017 | 0.75 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010003084-A2 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-01-07 | — | — | WO | disclosed |