Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 8/20 | 0.76 |
| ▸ | FNTA | P49354 | 12/20 | 0.60 |
| ▸ | FNTB | P49356 | 12/20 | 0.60 |
| ▸ | GRIA2 | P42262 | 5/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3135113 | 0.92 | GRIA4 (0.77) | GRIA4FNTAFNTBGRIA2 | |
| SCHEMBL3138457 | 0.90 | GRIA4 (0.71) | GRIA4FNTAFNTBGRIA2 | |
| SCHEMBL3139252 | 0.87 | FNTA (0.79) | GRIA4FNTAFNTBGRIA2 | |
| SCHEMBL3128889 | 0.86 | GRIA4 (1.00) | GRIA4FNTAFNTBGRIA2 | |
| SCHEMBL3137856 | 0.84 | GRIA4 (0.75) | GRIA4FNTAFNTBGRIA2 | |
| SCHEMBL3138042 | 0.83 | GRIA4 (0.71) | GRIA4FNTAFNTBGRIA2 | |
| SCHEMBL3131141 | 0.82 | GRIA4 (0.72) | GRIA4FNTAFNTBGRIA2 | |
| SCHEMBL10655268 | 0.80 | FNTA (0.60) | GRIA4FNTAFNTBGRIA2 | |
| SCHEMBL16798048 | 0.79 | FNTA (0.63) | GRIA4FNTAFNTB | |
| SCHEMBL3138552 | 0.79 | GRIA4 (0.57) | GRIA4FNTAFNTBGRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642361-B2 | Thiophene and furan compounds | ELI LILLY AND COMPANY (US) | 2010-01-05 | — | — | US | disclosed |
| US-7642361-B2 | Thiophene and furan compounds | ELI LILLY AND COMPANY (US) | 2010-01-05 | — | — | US | disclosed |
| US-20070105852-A1 | Thiophene and furan compounds | ELI LILLY AND COMPANY | 2007-05-10 | — | — | US | disclosed |
| US-20070105852-A1 | Thiophene and furan compounds | ELI LILLY AND COMPANY | 2007-05-10 | — | — | US | disclosed |
| EP-1706395-A1 | THIOPHENE AND FURAN COMPOUNDS | ELI LILLY AND COMPANY (US) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005070916-A1 | THIOPHENE AND FURAN COMPOUNDS | ELI LILLY AND COMPANY (US) | 2005-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105852-A1 | Thiophene and furan compounds | PSEN2, PSEN1, TPMT | GRIA4 15/4885FNTA 1089/4885FNTB 2103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.