Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 15/20 | 0.42 |
| ▸ | PDE4A | P27815 | 13/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.42 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | VEGFA | P15692 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3131372 | 0.94 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4DLTC4S | |
| SCHEMBL3129969 | 0.85 | PDE4B (0.57) | PDE4BPDE4APDE4CPDE4DPDE5A | |
| SCHEMBL3193408 | 0.85 | PDE4B (0.46) | PDE4BPDE4APDE4CPDE4DPDE5A | |
| SCHEMBL3123159 | 0.84 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DLTC4S | |
| SCHEMBL3128155 | 0.82 | PDE4B (0.46) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL3122601 | 0.80 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL3129519 | 0.79 | PDE4A (0.43) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL3131361 | 0.79 | PDE4A (0.43) | PDE4BPDE4APDE4CPDE4DLTC4S | |
| SCHEMBL3132055 | 0.78 | PDE4B (0.44) | PDE4BPDE4APDE4CPDE4DPDE5A | |
| SCHEMBL3118022 | 0.75 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DLTC4S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010003084-A2 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-01-07 | — | — | WO | disclosed |