Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.50 |
| ▸ | PLAU | P00749 | 2/20 | 0.50 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.50 |
| ▸ | ELANE | P08246 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31316910 | 0.86 | F2 (0.50) | F2PLAUKLKB1ELANEHTT | |
| SCHEMBL31710511 | 0.84 | KMT2A (0.49) | F2PLAUKLKB1ELANEHTT | |
| SCHEMBL31316940 | 0.84 | F2 (0.47) | F2PLAUKLKB1ELANEHTT | |
| SCHEMBL31316775 | 0.81 | F2 (0.44) | F2PLAUKLKB1ELANEHTT | |
| SCHEMBL31316909 | 0.81 | GSK3B (0.53) | F2PLAUKLKB1ELANEHTT | |
| SCHEMBL31316868 | 0.81 | MAPT (0.51) | F2PLAUKLKB1ELANEMAPK1 | |
| SCHEMBL31316915 | 0.81 | F2 (0.44) | F2PLAUKLKB1ELANEHTT | |
| SCHEMBL31316695 | 0.81 | HTT (0.49) | F2PLAUKLKB1ELANEHTT | |
| SCHEMBL9369399 | 0.79 | HTT (0.68) | F2PLAUKLKB1ELANEHTT | |
| SCHEMBL31316812 | 0.78 | HTT (0.47) | F2PLAUKLKB1ELANEHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4743453-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | Pretzel Therapeutics, Inc. (US) | 2026-05-20 | — | — | EP | disclosed |
| WO-2025015178-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | PRETZEL THERAPEUTICS, INC. (US) | 2025-01-16 | — | — | WO | disclosed |