Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 7/20 | 0.33 |
| ▸ | IKBKB | O14920 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | BMP1 | P13497 | 1/20 | 0.32 |
| ▸ | FBP1 | P09467 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 6/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RXRG | P48443 | 3/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3121517 | 0.84 | NR4A2 (0.40) | NR4A2TP53RAB9AKLF5SMN1; SMN2 | |
| SCHEMBL3129635 | 0.82 | NR4A2 (0.38) | NR4A2TP53RAB9AKLF5SMN1; SMN2 | |
| SCHEMBL13689101 | 0.76 | POLB (0.35) | POLBIKBKBMEN1KMT2ABMP1 | |
| SCHEMBL3742227 | 0.71 | POLB (0.44) | POLBIKBKBBMP1FBP1KDM4E | |
| SCHEMBL24158855 | 0.69 | NR4A2 (0.40) | NR4A2TP53RAB9AKLF5SMN1; SMN2 | |
| SCHEMBL3466896 | 0.68 | POLB (0.34) | POLBIKBKBBMP1FBP1KDM4E | |
| SCHEMBL18781937 | 0.67 | HCRTR1 (0.38) | — | |
| SCHEMBL4664039 | 0.67 | NR4A2 (0.41) | NR4A2TP53RAB9AKLF5SMN1; SMN2 | |
| SCHEMBL3822091 | 0.66 | NPSR1 (0.31) | KDM4EALDH1A1 | |
| SCHEMBL13056607 | 0.66 | POLB (0.39) | POLBIKBKBBMP1FBP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036632-A1 | AZAINDAZOLE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-04-01 | — | — | WO | disclosed |