Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.56 |
| ▸ | PDE5A | O76074 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23673431 | 0.87 | TSHR (0.59) | TSHRKDM4EALDH1A1LMNAMCOLN3 | |
| SCHEMBL4551788 | 0.84 | POLB (0.60) | TSHRKDM4EALDH1A1LMNAHTT | |
| SCHEMBL3124612 | 0.83 | TSHR (0.62) | TSHRKDM4EALDH1A1LMNAHTT | |
| Hydrochloric Acid SCHEMBL6196657 | 0.83 | POLB (0.61) | TSHRKDM4EALDH1A1LMNAHTT | |
| SCHEMBL5826839 | 0.82 | TSHR (0.60) | TSHRKDM4EALDH1A1LMNAHTT | |
| SCHEMBL4264787 | 0.82 | TSHR (0.60) | TSHRKDM4EALDH1A1LMNAHTT | |
| SCHEMBL5875799 | 0.81 | TSHR (0.59) | TSHRKDM4EALDH1A1LMNAHTT | |
| SCHEMBL5875796 | 0.80 | MEN1 (0.60) | TSHRKDM4EALDH1A1LMNAHTT | |
| SCHEMBL5875625 | 0.79 | TSHR (0.57) | TSHRKDM4EALDH1A1LMNAHTT | |
| SCHEMBL5827157 | 0.79 | CYP2C9 (0.65) | TSHRKDM4EALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168967-A1 | INTERMEDIATES FOR PREPARATION OF AN INHIBITOR OF PHOSPHODIESTERASE TYPE 5 | Galenicum Health, S.l. (ES) | 2010-03-31 | — | — | EP | disclosed |