Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2355012 | 0.90 | TTR (0.49) | TTRCYP3A4ALDH1A1NPSR1LMNA | |
| SCHEMBL347720 | 0.87 | HTT (0.47) | TTRALDH1A1NPSR1LMNAMEN1 | |
| SCHEMBL12515217 | 0.84 | TTR (0.46) | TTRCYP3A4ALDH1A1NPSR1LMNA | |
| SCHEMBL2365219 | 0.80 | TTR (0.56) | TTRCYP3A4ALDH1A1NPSR1LMNA | |
| SCHEMBL13521931 | 0.79 | TTR (0.49) | TTRCYP3A4ALDH1A1NPSR1LMNA | |
| SCHEMBL29560265 | 0.79 | TDP1 (0.58) | CYP3A4ALDH1A1TDP1NPSR1LMNA | |
| SCHEMBL922726 | 0.79 | TDP1 (0.58) | CYP3A4ALDH1A1TDP1NPSR1LMNA | |
| SCHEMBL21328360 | 0.79 | GAA (0.70) | CYP3A4CA5AGAAALDH1A1TSHR | |
| SCHEMBL4364148 | 0.78 | HSD17B10 (0.60) | GAAALDH1A1TDP1LMNAMEN1 | |
| SCHEMBL4847499 | 0.78 | HSD17B10 (0.60) | GAAALDH1A1TDP1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010003127-A2 | ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-01-07 | — | — | WO | disclosed |