Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 17/20 | 0.62 |
| ▸ | DDB1 | Q16531 | 6/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25843790 | 0.87 | CRBN (0.64) | CRBNDDB1HTTGAAPOLB | |
| SCHEMBL25843794 | 0.83 | HTT (0.60) | CRBNDDB1HTTGAAPOLB | |
| SCHEMBL25843897 | 0.82 | CRBN (0.57) | CRBNDDB1HTTGAAPOLB | |
| SCHEMBL26329288 | 0.81 | HTT (0.57) | CRBNDDB1HTTGAAPOLB | |
| SCHEMBL25122150 | 0.80 | CRBN (0.51) | CRBNDDB1HTTGAAPOLB | |
| SCHEMBL25843786 | 0.79 | CRBN (0.53) | CRBNDDB1HTTGAAPOLB | |
| SCHEMBL25122042 | 0.78 | CRBN (0.59) | CRBNDDB1HTTGAAPOLB | |
| SCHEMBL25187957 | 0.78 | CRBN (0.64) | CRBNDDB1POLB | |
| SCHEMBL19585871 | 0.78 | CRBN (0.71) | CRBNDDB1HTTGAAPOLB | |
| SCHEMBL24125814 | 0.78 | CRBN (0.64) | CRBNDDB1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4735438-A2 | HETEROBIFUNCTIONAL COMPOUNDS FOR THE DEGRADATION OF KRAS | Merck Patent GmbH (DE) | 2026-05-06 | — | — | EP | disclosed |
| EP-4735452-A2 | HETEROBIFUNCTIONAL COMPOUNDS FOR THE DEGRADATION OF KRAS PROTEIN | Merck Patent GmbH (DE) | 2026-05-06 | — | — | EP | disclosed |
| WO-2025006783-A2 | HETEROBIFUNCTIONAL COMPOUNDS FOR THE DEGRADATION OF KRAS | MERCK PATENT GMBH (DE) | 2025-01-02 | — | — | WO | disclosed |
| WO-2025006753-A2 | HETEROBIFUNCTIONAL COMPOUNDS FOR THE DEGRADATION OF KRAS PROTEIN | MERCK PATENT GMBH (DE) | 2025-01-02 | — | — | WO | disclosed |