Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | ACACA | Q13085 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31093794 | 0.86 | MAPKAPK2 (0.39) | MAPKAPK2BRAFATRPOLBDGAT1 | |
| SCHEMBL27141821 | 0.83 | ATR (0.42) | MAPKAPK2BRAFATRCYP17A1AAK1 | |
| SCHEMBL25136736 | 0.81 | ATR (0.40) | MAPKAPK2ATRCYP17A1AAK1BRD9 | |
| SCHEMBL25137117 | 0.81 | ATR (0.40) | MAPKAPK2ATRPOLBCYP17A1AAK1 | |
| SCHEMBL30050497 | 0.80 | ATR (0.37) | MAPKAPK2BRAFATRNPSR1DGAT1 | |
| SCHEMBL29023131 | 0.80 | ATR (0.37) | MAPKAPK2BRAFATRNPSR1DGAT1 | |
| SCHEMBL25136697 | 0.80 | ATR (0.40) | MAPKAPK2ATRCYP17A1AAK1BRD9 | |
| SCHEMBL26709368 | 0.79 | RXFP1 (0.40) | MAPKAPK2ATRPOLBCYP17A1AAK1 | |
| SCHEMBL21783471 | 0.78 | BRAF (0.41) | MAPKAPK2BRAFATRCYP17A1DGAT1 | |
| SCHEMBL30045766 | 0.78 | BRAF (0.41) | MAPKAPK2BRAFATRCYP17A1DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4735438-A2 | HETEROBIFUNCTIONAL COMPOUNDS FOR THE DEGRADATION OF KRAS | Merck Patent GmbH (DE) | 2026-05-06 | — | — | EP | disclosed |
| WO-2025006783-A2 | HETEROBIFUNCTIONAL COMPOUNDS FOR THE DEGRADATION OF KRAS | MERCK PATENT GMBH (DE) | 2025-01-02 | — | — | WO | disclosed |