Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 15/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 15/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31323505 | 0.84 | DDB1 (0.54) | DDB1CRBNGPR119 | |
| SCHEMBL31727881 | 0.84 | DDB1 (0.56) | DDB1CRBNCYP11B2BACE1GPR119 | |
| SCHEMBL31323623 | 0.83 | DDB1 (0.41) | DDB1CRBN | |
| SCHEMBL31323670 | 0.81 | DDB1 (0.50) | DDB1CRBN | |
| SCHEMBL29321735 | 0.80 | DDB1 (0.48) | DDB1CRBN | |
| SCHEMBL31443980 | 0.80 | DDB1 (0.52) | DDB1CRBNGPR119 | |
| SCHEMBL25604357 | 0.80 | DDB1 (0.52) | DDB1CRBNGPR119 | |
| SCHEMBL31323414 | 0.80 | PDK4 (0.49) | DDB1CRBN | |
| SCHEMBL29324512 | 0.79 | DDB1 (0.48) | DDB1CRBN | |
| SCHEMBL31443625 | 0.79 | DDB1 (0.51) | DDB1CRBNBACE1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4735452-A2 | HETEROBIFUNCTIONAL COMPOUNDS FOR THE DEGRADATION OF KRAS PROTEIN | Merck Patent GmbH (DE) | 2026-05-06 | — | — | EP | disclosed |
| WO-2025006753-A2 | HETEROBIFUNCTIONAL COMPOUNDS FOR THE DEGRADATION OF KRAS PROTEIN | MERCK PATENT GMBH (DE) | 2025-01-02 | — | — | WO | disclosed |